Skip to content
Register Sign in Wishlist
Look Inside Genetic Variation and Human Disease

Genetic Variation and Human Disease
Principles and Evolutionary Approaches

$58.00 (P)

Part of Cambridge Studies in Biological and Evolutionary Anthropology

  • Date Published: January 1995
  • availability: Available
  • format: Paperback
  • isbn: 9780521336604

$ 58.00 (P)
Paperback

Add to cart Add to wishlist

Looking for an examination copy?

If you are interested in the title for your course we can consider offering an examination copy. To register your interest please contact collegesales@cambridge.org providing details of the course you are teaching.

Description
Product filter button
Description
Contents
Resources
Courses
About the Authors
  • Modern laboratory and computing advances have made it possible to identify which genes are responsible for a disease (or other biological traits) and to identify those genes. This book presents a survey of the methods that are being used to generate these successes, especially to study disease in families. The methods of epidemiology and genetics are surveyed, and related to molecular genetic data, with examples from both pediatric and chronic disease. The pattern of variation that has been found is best understood from the evolutionary perspective. Because these methods and ideas apply to any biological trait, not just to disease, this is a general book about the genetic control of biological traits.

    • Topical subject (human genome project is very high profile)
    • Good reviews for hardback edition
    • No other up-to-date book covers this range of topics
    Read more

    Reviews & endorsements

    "...a most useful reference for those who wish to familiarize themselves with the area in general and to gain some comprehension of its methodologies." Roger W. Melvold, Doody's Health Science Book Review Journal

    "...provides an overview of the concepts and methods needed to understand the genetic basis of biological traits, including disease, in humans. Using examples of qualitative and quantitative phenotypes, Professor Weiss shows how genetic variation may be quantified, and how relationships between genotype and phenotype may be inferred....will appeal to a wide range of biologists and biological anthropologists interested in the genetic basis of biological traits, as well as to epidemiologists, biomedical scientists, human geneticists and molecular biologists." Human Genome Abstracts

    "...provides a comprehensive yet readable account of concepts and methods new to genetic epidemiology and molecular biology, which allows examination of the genetic basis of biological traits." N. Krusko, Choice

    "...well-documented, clearly written, scholarly text...will certainly be valuable to students of genetics, epidemiology, molecular biology and biological anthropology, and to all who are interested in solving the molecular etiology of disease phenotypes and in studying the human gene pool and its behavior throughout evolution." Trends in Genetics

    "...the value of the book lies in the mixing of quantitative methods of empirical findings of modern biology." Jonathan Flint, Times Higher Education Supplement

    "This is a very fine and rewarding work. We find here no less than an explanation of the current status of, and a means for understanding, the rising flood of information on human genetic variability." William Klitz, Quarterly Review of Biology

    See more reviews

    Customer reviews

    Not yet reviewed

    Be the first to review

    Review was not posted due to profanity

    ×

    , create a review

    (If you're not , sign out)

    Please enter the right captcha value
    Please enter a star rating.
    Your review must be a minimum of 12 words.

    How do you rate this item?

    ×

    Product details

    • Date Published: January 1995
    • format: Paperback
    • isbn: 9780521336604
    • length: 380 pages
    • dimensions: 229 x 152 x 21 mm
    • weight: 0.56kg
    • contains: 71 b/w illus. 42 tables
    • availability: Available
  • Table of Contents

    Preface
    Part I. Genes and Their Expression:
    1. What is a gene?
    2. The logic of the genome
    3. Concepts of frequency and association in populations
    4. Genes and phenotypes in populations
    Part II. Introduction to Genetic Epidemiology: Inference from Observational Data:
    5. Segregation analysis: discrete traits in families
    6. Segregation analysis: quantitative traits in families
    7. Linkage analysis: finding and mapping genes for qualitative traits
    8. Linkage analysis: finding and mapping genes for quantitative traits
    Part III. Evolution: The Time Dimension in Populations:
    9. Genes over time and space
    10. Reconstructing history: the footprints of evolution
    11. Evolution generates heterogeneity
    Part IV. Modification of the Inherited Genotype: The Time Dimension in Individuals:
    12. Phenotype amplification by the environment
    13. Infectious disease: the response to biological challenge
    14. Variation within the inherited genotype
    15. Cancer and ageing: a microcosm of evolution during life
    Afterwords: towards a unified general model
    Conclusion
    Notes
    References
    Index.

  • Author

    Kenneth M. Weiss, Pennsylvania State University

Sign In

Please sign in to access your account

Cancel

Not already registered? Create an account now. ×

Sorry, this resource is locked

Please register or sign in to request access. If you are having problems accessing these resources please email lecturers@cambridge.org

Register Sign in
Please note that this file is password protected. You will be asked to input your password on the next screen.

» Proceed

You are now leaving the Cambridge University Press website. Your eBook purchase and download will be completed by our partner www.ebooks.com. Please see the permission section of the www.ebooks.com catalogue page for details of the print & copy limits on our eBooks.

Continue ×

Continue ×

Continue ×

Find content that relates to you

Join us online

This site uses cookies to improve your experience. Read more Close

Are you sure you want to delete your account?

This cannot be undone.

Cancel

Thank you for your feedback which will help us improve our service.

If you requested a response, we will make sure to get back to you shortly.

×
Please fill in the required fields in your feedback submission.
×