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Apoptosis
Physiology and Pathology

$125.00 ( ) USD

  • Editor: John C. Reed, Sanford-Burnham Medical Research Institute, La Jolla, California
  • Author: Douglas R. Green, St. Jude Children's Research Hospital, Memphis, Tennessee
Guy S. Salvesen, Jason B. Garrison, Andreas Krieg, Kate Welsh, Yunfei Wen, John C. Reed, Henning Walczak, Chahrazade Kantari, Gavin P. McStay, Douglas R. Green, Anthony Letai, Michael Boyce, Marta M. Lipinski, Bénédicte F. Py, Junying Yuan, Hiroshi Koga, Ana Maria Cuervo, Pablo Lopez-Bergami, Ze'ev Ronai, Thomas D. Mullen, Russell W. Jenkins, Lina M. Obeid, Yusuf A. Hannun, Katherine Baran, Ilia Voskoboinik, Nigel J. Waterhouse, Vivien R. Sutton, Joseph A. Trapani, Juying Li, Junying Yuan, Dale E. Bredesen, Tomohiro Nakamura, Stuart A. Lipton, Lucian Soane, Brian M. Polster, Gary Fiskum, Rajiv R. Ratan, Moses V. Chao, Jerry Y. Niederkorn, Lisa L. Cunningham, Justin Tan, Pawel Kermer, Nika N. Danial, Christian Taube, Martin Schuler, Maria Eugenia Guicciardi, Gregory J. Gores, Juan Antonio Moreno, Adrian Mario Ramos, Alberto Ortiz, Armelle Melet, Roya Khosravi-Far, Kaisa Selesniemi, Jonathan L. Tilly, Amiya P. Sinha Hikim, Yue Jia, Yan-He Lue, Christina Wang, Ronald S. Swerdloff, Vladimir Kaplinskiy, Martin R. Bennett, Richard N. Kitsis, Ayesha Saleem, Lawrence Kazak, Michael O'Leary, David A. Hood, Saskia Lippens, Esther Hoste, Peter Vandenabeele, Wim Declercq, Delphine Mérino, Philippe Bouillet, Paul A. Ney, Pavan Brahmamdam, Jared T. Muenzer, Richard S. Hotchkiss, Jonathan E. McDunn, Maya Saleh, Valter D. Longo, Cristina Mazzoni, Brian L. Harry, Ding Xue, Kathleen Galindo, John M. Abrams, Ujwal J. Pyati, A. Thomas Look
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  • Date Published: December 2011
  • availability: This ISBN is for an eBook version which is distributed on our behalf by a third party.
  • format: Adobe eBook Reader
  • isbn: 9781139118552

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  • Apoptosis, or cell death, can be pathological, a sign of disease and damage, or physiological, a process essential for normal health. This pathological dysregulation of cell death can be characterized by either too much loss of essential cells in the heart, brain, and other tissues with little regenerative capacity or by too little cell turnover in self-renewing tissues, giving rise to cancer and other maladies. This is a process of fundamental importance for development and normal health, which is altered in many disease conditions. This book, with contributions from experts in the field, provides a timely compilation of reviews of mechanisms of apoptosis. The book is organized into three convenient sections. The first section explores the different processes of cell death and how they relate to one another. The second section focuses on organ-specific apoptosis-related diseases. The third section explores cell death in non-mammalian organisms, such as plants. This comprehensive text is a must-read for all researchers and scholars interested in apoptosis.

    • A comprehensive text on all areas of apoptosis, from a fundamental understanding of the different processes to apoptosis-related diseases
    • This edited volume includes contributions from the top experts and researchers who study cell death
    • Discusses cell death in non-mammalian organisms
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    Product details

    • Date Published: December 2011
    • format: Adobe eBook Reader
    • isbn: 9781139118552
    • contains: 74 b/w illus. 47 colour illus. 21 tables
    • availability: This ISBN is for an eBook version which is distributed on our behalf by a third party.
  • Table of Contents

    Part I. General Principles of Cell Death:
    1. Human caspases – apoptosis and inflammation signaling proteases Guy S. Salvesen
    2. Inhibitor of apoptosis proteins Jason B. Garrison, Andreas Krieg, Kate Welsh, Yunfei Wen and John C. Reed
    3. Death domain-containing receptors: decisions between suicide and fire Henning Walczak and Chahrazade Kantari
    4. Mitochondria and cell death Gavin P. McStay and Douglas R. Green
    5. BCL-2 family proteins and the control of mitochondrial apoptosis Anthony Letai
    6. Endoplasmic reticulum stress response in cell death and cell survival Michael Boyce, Marta M. Lipinski, Bénédicte F. Py and Junying Yuan
    7. Autophagy: the liaison between the lysosomal system and cell death Hiroshi Koga and Ana Maria Cuervo
    8. Cell death in response to genotoxic stress and DNA damage Pablo Lopez-Bergami and Ze'ev Ronai
    9. Ceramide and lipid mediators in apoptosis Thomas D. Mullen, Russell W. Jenkins, Lina M. Obeid and Yusuf A. Hannun
    10. Cytotoxic granules house potent pro-apoptotic toxins critical for anti-viral responses and immune homeostasis Katherine Baran, Ilia Voskoboinik, Nigel J. Waterhouse, Vivien R. Sutton and Joseph A. Trapani
    Part II. Cell Death in Tissues and Organs:
    11. Cell death in nervous system development and neurological disease Juying Li and Junying Yuan
    12. Role of programmed cell death in neurodegenerative diseases Dale E. Bredesen
    13. Implications of nitrosative stress-induced protein misfolding in neurodegeneration Tomohiro Nakamura and Stuart A. Lipton
    14. Mitochondrial mechanisms of neural cell death in cerebral ischemia Lucian Soane, Brian M. Polster and Gary Fiskum
    15. Cell death in spinal cord injury: an evolving taxonomy with therapeutic promise Rajiv R. Ratan and Moses V. Chao
    16. Apoptosis and homeostasis in the eye Jerry Y. Niederkorn
    17. Cell death in the inner ear Lisa L. Cunningham and Justin Tan
    18. Cell death in the olfactory system Pawel Kermer
    19. Apoptosis regulation of the endocrine pancreas and pathophysiology of diabetes Nika N. Danial
    20. Apoptosis in the physiology and diseases of the respiratory tract Christian Taube and Martin Schuler
    21. Regulation of cell death in the gastrointestinal track Maria Eugenia Guicciardi and Gregory J. Gores
    22. Apoptosis in the kidney Juan Antonio Moreno, Adrian Mario Ramos and Alberto Ortiz
    23. Physiological and pathological cell death in the mammary gland Armelle Melet and Roya Khosravi-Far
    24. Apoptosis in the female reproductive biology – implications for therapy Kaisa Selesniemi and Jonathan L. Tilly
    25. Apoptotic signaling in male germ cells Amiya P. Sinha Hikim, Yue Jia, Yan-He Lue, Christina Wang and Ronald S. Swerdloff
    26. Cell death in the cardiovascular system Vladimir Kaplinskiy, Martin R. Bennett and Richard N. Kitsis
    27. Cell death regulation in muscle Ayesha Saleem, Lawrence Kazak, Michael O'Leary and David A. Hood
    28. Cell death in the skin Saskia Lippens, Esther Hoste, Peter Vandenabeele and Wim Declercq
    29. Apoptosis and cell survival in the immune system Delphine Mérino and Philippe Bouillet
    30. Cell death regulations in the hematopoietic system Paul A. Ney
    31. Apoptotic cell death in sepsis Pavan Brahmamdam, Jared T. Muenzer, Richard S. Hotchkiss and Jonathan E. McDunn
    32. Host-pathogen interactions Maya Saleh
    Part III. Cell Death in Non-Mammalian Organisms:
    33. Programmed cell death in the yeast, S. cerevisiae Valter D. Longo and Cristina Mazzoni
    34. C. elegans and apoptosis Brian L. Harry and Ding Xue
    35. Apoptotic cell death in drosophila Kathleen Galindo and John M. Abrams
    36. Analysis of cell death in zebrafish Ujwal J. Pyati and A. Thomas Look.

  • Editor

    John C. Reed, Sanford-Burnham Medical Research Institute, La Jolla, California
    John C. Reed is Chief Executive Officer of the Sanford-Burnham Medical Research Institute. Dr Reed is also Professor and Donald Bren Executive Chair at Sanford-Burnham, with adjunct professor appointments at several universities. Dr Reed is the recipient of numerous awards and honors and has been awarded more than 76 research grants for his work. He is a named inventor for more than 99 patents and the founder or co-founder of four biotechnology companies. Dr Reed has served as an advisor to numerous biotechnology and pharmaceutical companies and has also served on the boards of directors of several public and private biotechnology companies and life-sciences organizations.

    Author

    Douglas R. Green, St. Jude Children's Research Hospital, Memphis, Tennessee
    Douglas R. Green is Chair of the Department of Immunology at St Jude Children's Research Hospital, where he also holds the Peter Doherty Endowed Chair. Dr Green came to St Jude in 2005, prior to which he was Head of the Division of Cellular Immunology at the La Jolla Institute of Allergy and Immunology. Dr Green serves as an editor for a number of leading journals and is editor-in-chief of the journal Oncogene.

    Contributors

    Guy S. Salvesen, Jason B. Garrison, Andreas Krieg, Kate Welsh, Yunfei Wen, John C. Reed, Henning Walczak, Chahrazade Kantari, Gavin P. McStay, Douglas R. Green, Anthony Letai, Michael Boyce, Marta M. Lipinski, Bénédicte F. Py, Junying Yuan, Hiroshi Koga, Ana Maria Cuervo, Pablo Lopez-Bergami, Ze'ev Ronai, Thomas D. Mullen, Russell W. Jenkins, Lina M. Obeid, Yusuf A. Hannun, Katherine Baran, Ilia Voskoboinik, Nigel J. Waterhouse, Vivien R. Sutton, Joseph A. Trapani, Juying Li, Junying Yuan, Dale E. Bredesen, Tomohiro Nakamura, Stuart A. Lipton, Lucian Soane, Brian M. Polster, Gary Fiskum, Rajiv R. Ratan, Moses V. Chao, Jerry Y. Niederkorn, Lisa L. Cunningham, Justin Tan, Pawel Kermer, Nika N. Danial, Christian Taube, Martin Schuler, Maria Eugenia Guicciardi, Gregory J. Gores, Juan Antonio Moreno, Adrian Mario Ramos, Alberto Ortiz, Armelle Melet, Roya Khosravi-Far, Kaisa Selesniemi, Jonathan L. Tilly, Amiya P. Sinha Hikim, Yue Jia, Yan-He Lue, Christina Wang, Ronald S. Swerdloff, Vladimir Kaplinskiy, Martin R. Bennett, Richard N. Kitsis, Ayesha Saleem, Lawrence Kazak, Michael O'Leary, David A. Hood, Saskia Lippens, Esther Hoste, Peter Vandenabeele, Wim Declercq, Delphine Mérino, Philippe Bouillet, Paul A. Ney, Pavan Brahmamdam, Jared T. Muenzer, Richard S. Hotchkiss, Jonathan E. McDunn, Maya Saleh, Valter D. Longo, Cristina Mazzoni, Brian L. Harry, Ding Xue, Kathleen Galindo, John M. Abrams, Ujwal J. Pyati, A. Thomas Look

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