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This concise overview of the fundamental concepts of cancer biology is ideal for those with little or no background in the field. A summary of global cancer patterns introduces students to the general principles of how cancers arise and the risk factors involved. By focusing on fundamental examples of the signalling pathways within cells, the functional effects of DNA damage are explained. Later chapters then build on this foundation to provide a comprehensive summary of the major signalling pathways that affect tumour development. Current therapeutic strategies are reviewed, along with a discussion of methods for tumour detection and biomarker identification. Finally, the impact of whole genome sequencing is discussed, bringing students up to date with key recent developments in the field. From basic principles to insights into cutting-edge research, this book will enable the reader to move into the cancer field with confidence.Read more
- Concise overview of the current picture of cancer biology for students with little or no background knowledge of the field
- Provides a unique summary of the ten major cancers, from risk factors and gene mutations to symptoms and treatments
- Explains the relevance of recent progress in genomics and proteomics for cancer treatment and diagnostics
Reviews & endorsements
"Cancer biology and cancer medicine are broad and extensive fields with fast moving research developing new knowledge of many aspects of cancer. Modern technologies are increasing the pace of acquisition of new knowledge and contributing to real progress in managing patients.
Robin Hesketh has produced a remarkable Introduction to Cancer Biology which covers all of the key areas of current knowledge and brings them up to date with current research concepts and developments. He writes in an accessible way that will be valuable for students fresh to biology but also produces a book that will be very useful to experienced biologists and physicians who want to have to hand a broad overview of this fast moving and diverse field.
The structure of the book is clear and informative and encompasses critically important biological knowledge from the level of the cell to population studies in epidemiology. The appendices are very useful providing ready access to information on most common cancer and most of the major tabulations of existing knowledge that we may need.
In the era of internet access and publication databases, it is very challenging to introduce a book which is really useful both for new students and established practitioners. Robin Hesketh has succeeded remarkably well in doing so."
Professor Peter Selby, Director of the Leeds Institute of Molecular MedicineSee more reviews
"The structure of the book is clear and well organized. The author writes well, giving excellent explanations of concepts ranging from basic principles to cutting-edge research. The book is a valuable resource for introducing lower-level students to the biology of cancer. Highly recommended."
H. Zhou, Seton Hall University for Choice Magazine
Review was not posted due to profanity×
- Date Published: December 2012
- format: Adobe eBook Reader
- isbn: 9781139847971
- contains: 130 b/w illus. 38 colour illus.
- availability: This ISBN is for an eBook version which is distributed on our behalf by a third party.
Table of Contents
1. Lessons from epidemiology
2. Causes of cancer
3. Signalling in normal cells
4. 'Cancer genes': mutations and cancer development
5. What is a tumour?
6. Cancer signalling networks
7. The future of cancer prevention, diagnosis and treatment
8. The future of cancer in the post-genomic era
Ten major cancers at a glance
Appendix. Targets of specific anti-cancer drugs
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