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Limb Regeneration

Limb Regeneration

Out of Print

Part of Developmental and Cell Biology Series

  • Date Published: July 1996
  • availability: Unavailable - out of print October 2008
  • format: Hardback
  • isbn: 9780521441490

Out of Print

Unavailable - out of print October 2008
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About the Authors
  • The complex phenomenon of limb regeneration that occurs in some Amphibia involves unique molecular and cellular mechanisms. When a limb is amputated a new one is produced by the transformation of the remaining adult limb tissues into an embryonic-like cell mass, called the blastema. The blastema has the ability to subsequently redifferentiate into the various tissues that comprise a limb and therefore replace the lost part. Some scientists argue that the same processes that are encountered in normal embryogenesis are reinitiated during regeneration. This is the first book that describes and analyzes the mechanisms of both limb regeneration and patterning by incorporating the information obtained from older experiments with the many new advances in molecular and cellular biology that have occurred in recent years.

    • A unique synthesis of mechanisms of cell differentiation during limb regeneration and patterning
    • Offers insights into molecular and cellular mechanisms of limb regeneration
    • Bridges the old experiments with new advances in molecular and cellular biology
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    Reviews & endorsements

    "This is certainly an interesting book which all readers, even if not interested in the given field, may read because of the elegant manner in which it is written and the numerous interesting points having been evoked." Cellular and Molecular Biology

    "Extensive and thorough....a worthwhile library purchase." F.W. Yow, Choice

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    Product details

    • Date Published: July 1996
    • format: Hardback
    • isbn: 9780521441490
    • length: 255 pages
    • dimensions: 236 x 155 x 21 mm
    • weight: 0.576kg
    • contains: 68 b/w illus. 4 colour illus. 7 tables
    • availability: Unavailable - out of print October 2008
  • Table of Contents

    1. Capacity of limb regeneration in vertebrates
    2. The amputation - the early events
    3. The beginning of regeneration - wound epithelium
    4. Dedifferentiation and origin of the blastema
    5. Differentiation of the blastema
    6. Nerve dependence of regeneration
    7. Protein synthesis in the blastema
    8. Limb cells in vitro
    9. Tissue vs. Epimorphic regeneration
    10. Bioelectricity and limb regeneration
    11. Post-embryonic induction in amphibian limbs
    12. Stimulation and inhibition of regeneration
    13. Genetics and limb regeneration
    14. Models for pattern formation
    15. Morphogenetic properties of the blastema
    16. The regeneration of positional information
    17. Vitamin A and patterning
    18. Hox genes and limb regeneration
    19. Regenerating CSH developing limbs
    20. Molecular advances

  • Author

    Panagiotis A. Tsonis, University of Dayton, Ohio

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