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Principles of Pharmacogenetics and Pharmacogenomics

$100.00 ( ) USD

Russ Altman, David Flockhart, David Goldstein, James K. Burmester, Ingrid Glurich, Kimberly Pillsbury, Michael D. Caldwell, Sharon Marsh, Cristi R. King, Terry Blaschke, Matthew Nelson, Li Gong, Teri E. Klein, David S. Wishart, Sandra Lee, Mark Rothstein, Barbara Evans, Uchenna Njaju, Eileen Dolan, Michael Stein, Danny Kurnik, Ronald M. Krauss, Russell A. Wilke, Melissa Antonik, Elenita Kanin, Dan M. Roden, Prince J. Kannankeril, Stefan Kaab, Dawood Darbar, O. H. Klungel, Mark C. H. DeGroot, Kelan Tantisira, Scott Weiss, Takahisa Furuta, Robert M. Plenge, Yvonne C. Lee, Souomya Raychaudhuri, Daniel H. Solomon, David Haas, Jamie Renbarger, David Mrazeks, Evan Kharasch, Konrad Meissner, Amalio Telenti, Jennifer A. Lowry, J. Steven Leeder, Yair Blumenfeld
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  • Date Published: March 2012
  • availability: This ISBN is for an eBook version which is distributed on our behalf by a third party.
  • format: Adobe eBook Reader
  • isbn: 9781139227568

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  • The study of pharmacogenetics and pharmacogenomics focuses on how our genes and complex gene systems influence our response to drugs. Recent progress in the science of clinical therapeutics has led to the discovery of new biomarkers that make it technically easier to identify groups of patients which are more or less likely to respond to individual therapies. The aim is to improve personalised medicine - not simply to prescribe the right medicine, but to deliver the right drug at the right dose at the right time. This textbook brings together contributions from leading experts to discuss the latest information on how human genetics impacts drug response phenotypes. It presents not only the basic principles of pharmacogenetics, but also clinically valuable examples that cover a broad range of specialties and therapeutic areas. The first section of the book outlines critical concepts in pharmacogenetics and pharmacogenomics, including genetic testing, genotyping technologies, and adverse drug effects. The next section discusses the legal, ethical, and social implications of pharmacogenomics. The second half of the book details many of the main therapeutic areas, including oncologic drugs, cardiovascular drugs, statins, drug-induced long QT syndrome, diabetes drugs, respiratory drugs, gastrointestinal drugs, rheumatoid arthritis drugs, obstetric drugs, psychiatric drugs, pain and anesthesia drugs, HIV and antiretroviral drugs, pediatrics, and fetal and neonatal medicine. This textbook is an invaluable introduction to pharmacogenetics and pharmacogenomics for health care professionals, medical students, pharmacy students, graduate students and researchers in the biosciences. RESOURCES @ www.cambridge.org/altman • Link to the Pharmacogenomics Knowledgebase • study guides • images from the book • discussion questions • content updates.

    • This text provides state-of-the-art information on developments in pharmacogenetics and pharmacogenomics
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    Product details

    • Date Published: March 2012
    • format: Adobe eBook Reader
    • isbn: 9781139227568
    • contains: 27 b/w illus. 77 colour illus. 26 tables 37 exercises
    • availability: This ISBN is for an eBook version which is distributed on our behalf by a third party.
  • Table of Contents

    Introduction to population diversity and genetic testing: basic concepts Russ Altman, David Flockhart and David Goldstein
    Part I. Critical Concepts:
    1. Introduction to population diversity and genetic testing James K. Burmester, Ingrid Glurich, Kimberly Pillsbury and Michael D. Caldwell
    2. Genotyping technologies Sharon Marsh and Cristi R. King
    3. Pharmacokinetics: absorption, distribution, metabolism, excretion Terry Blaschke
    4. Overview: adverse drug reactions Matthew Nelson
    5. PharmGKB, a centralized resource for pharmacogenomic knowledge and discovery Li Gong and Teri E. Klein
    6. DrugBank David S. Wishart
    7. Ethical considerations for pharmacogenomics: privacy and confidentiality Sandra Lee
    8. Informed consent in pharmacogenomic research and treatment Mark Rothstein
    9. Legal trends driving the clinical translation of pharmacogenomics Barbara Evans
    Part II. Therapeutic Areas:
    10. Pharmacogenetics of oncologic drugs Uchenna Njaju and Eileen Dolan
    11. Pharmacogenetics of cardiovascular drugs Michael Stein and Danny Kurnik
    12. Pharmacogenomics of statin-induced muscle toxicity Ronald M. Krauss, Russell A. Wilke, Melissa Antonik and Elenita Kanin
    13. Pharmacogenomics of the drug-induced long QT syndrome Dan M. Roden, Prince J. Kannankeril, Stefan Kaab and Dawood Darbar
    14. Pharmacogenetics of diabetes drugs O. H. Klungel and Mark C. H. DeGroot
    15. Pharmacogenetics of respiratory drugs Kelan Tantisira and Scott Weiss
    16. Pharmacogenomics for acid-related gastrointestinal drugs Takahisa Furuta
    17. Pharmacogenetics of rheumatoid arthritis drugs Robert M. Plenge, Yvonne C. Lee, Souomya Raychaudhuri and Daniel H. Solomon
    18. Pharmacogenomics of obstetric drugs David Haas and Jamie Renbarger
    19. Pharmacogenomics of psychiatric drugs David Mrazek
    20. Pharmacogenomics of pain and anesthesia drugs Evan Kharasch and Konrad Meissner
    21. Pharmacogenetics of HIV and antiretroviral drugs Amalio Telenti
    22. Pharmacogenomics in pediatrics Jennifer A. Lowry and J. Steven Leeder
    23. Pharmacogenomics in fetal and neonatal medicine Yair Blumenfeld.

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    Principles of Pharmacogenetics and Pharmacogenomics

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  • Instructors have used or reviewed this title for the following courses

    • Intro to Pharmacogenetics
    • Pharmacogenomics
    • Pharmacogenomics & Biotechnology
    • Principles of Pharmacogenomics
  • Editors

    Russ B. Altman, Stanford University, California
    Russ Altman is Chairman of the Bioengineering Department and Professor of Bioengineering, Genetics, and Medicine at Stanford University. His primary research interests are in the application of computing technology to basic molecular biological problems of relevance to medicine.

    David Flockhart, Indiana University
    David Flockhart is the Harry and Edith Gladstein Chair in Cancer Genomics and Professor of Medicine, Medical Genetics and Pharmacology at the Indiana University School of Medicine in Indianapolis. He is also the Director of the Division of Clinical Pharmacology. His research is focused on clinically relevant applications of pharmacogenetics and drug interactions.

    David B. Goldstein, Duke University, North Carolina
    David Goldstein is the Richard and Pat Johnson Distinguished University Professor and Director of the Center for Human Genome Variation at Duke University. He is also Professor of Molecular Genetics and Microbiology at Duke. His principal interests include human genetic diversity, the genetics of disease and pharmacogenetics.

    Contributors

    Russ Altman, David Flockhart, David Goldstein, James K. Burmester, Ingrid Glurich, Kimberly Pillsbury, Michael D. Caldwell, Sharon Marsh, Cristi R. King, Terry Blaschke, Matthew Nelson, Li Gong, Teri E. Klein, David S. Wishart, Sandra Lee, Mark Rothstein, Barbara Evans, Uchenna Njaju, Eileen Dolan, Michael Stein, Danny Kurnik, Ronald M. Krauss, Russell A. Wilke, Melissa Antonik, Elenita Kanin, Dan M. Roden, Prince J. Kannankeril, Stefan Kaab, Dawood Darbar, O. H. Klungel, Mark C. H. DeGroot, Kelan Tantisira, Scott Weiss, Takahisa Furuta, Robert M. Plenge, Yvonne C. Lee, Souomya Raychaudhuri, Daniel H. Solomon, David Haas, Jamie Renbarger, David Mrazeks, Evan Kharasch, Konrad Meissner, Amalio Telenti, Jennifer A. Lowry, J. Steven Leeder, Yair Blumenfeld

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