Principles of Pharmacogenetics and Pharmacogenomics
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- Russ B. Altman, Stanford University, California
- David Flockhart, Indiana University
- David B. Goldstein, Duke University, North Carolina
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The study of pharmacogenetics and pharmacogenomics focuses on how our genes and complex gene systems influence our response to drugs. Recent progress in the science of clinical therapeutics has led to the discovery of new biomarkers that make it technically easier to identify groups of patients which are more or less likely to respond to individual therapies. The aim is to improve personalised medicine - not simply to prescribe the right medicine, but to deliver the right drug at the right dose at the right time. This textbook brings together contributions from leading experts to discuss the latest information on how human genetics impacts drug response phenotypes. It presents not only the basic principles of pharmacogenetics, but also clinically valuable examples that cover a broad range of specialties and therapeutic areas. The first section of the book outlines critical concepts in pharmacogenetics and pharmacogenomics, including genetic testing, genotyping technologies, and adverse drug effects. The next section discusses the legal, ethical, and social implications of pharmacogenomics. The second half of the book details many of the main therapeutic areas, including oncologic drugs, cardiovascular drugs, statins, drug-induced long QT syndrome, diabetes drugs, respiratory drugs, gastrointestinal drugs, rheumatoid arthritis drugs, obstetric drugs, psychiatric drugs, pain and anesthesia drugs, HIV and antiretroviral drugs, pediatrics, and fetal and neonatal medicine. This textbook is an invaluable introduction to pharmacogenetics and pharmacogenomics for health care professionals, medical students, pharmacy students, graduate students and researchers in the biosciences. RESOURCES @ www.cambridge.org/altman • Link to the Pharmacogenomics Knowledgebase • study guides • images from the book • discussion questions • content updates.Read more
- This text provides state-of-the-art information on developments in pharmacogenetics and pharmacogenomics
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- Date Published: March 2012
- format: Adobe eBook Reader
- isbn: 9781139227568
- contains: 27 b/w illus. 77 colour illus. 26 tables 37 exercises
- availability: This ISBN is for an eBook version which is distributed on our behalf by a third party.
Table of Contents
Introduction to population diversity and genetic testing: basic concepts Russ Altman, David Flockhart and David Goldstein
Part I. Critical Concepts:
1. Introduction to population diversity and genetic testing James K. Burmester, Ingrid Glurich, Kimberly Pillsbury and Michael D. Caldwell
2. Genotyping technologies Sharon Marsh and Cristi R. King
3. Pharmacokinetics: absorption, distribution, metabolism, excretion Terry Blaschke
4. Overview: adverse drug reactions Matthew Nelson
5. PharmGKB, a centralized resource for pharmacogenomic knowledge and discovery Li Gong and Teri E. Klein
6. DrugBank David S. Wishart
7. Ethical considerations for pharmacogenomics: privacy and confidentiality Sandra Lee
8. Informed consent in pharmacogenomic research and treatment Mark Rothstein
9. Legal trends driving the clinical translation of pharmacogenomics Barbara Evans
Part II. Therapeutic Areas:
10. Pharmacogenetics of oncologic drugs Uchenna Njaju and Eileen Dolan
11. Pharmacogenetics of cardiovascular drugs Michael Stein and Danny Kurnik
12. Pharmacogenomics of statin-induced muscle toxicity Ronald M. Krauss, Russell A. Wilke, Melissa Antonik and Elenita Kanin
13. Pharmacogenomics of the drug-induced long QT syndrome Dan M. Roden, Prince J. Kannankeril, Stefan Kaab and Dawood Darbar
14. Pharmacogenetics of diabetes drugs O. H. Klungel and Mark C. H. DeGroot
15. Pharmacogenetics of respiratory drugs Kelan Tantisira and Scott Weiss
16. Pharmacogenomics for acid-related gastrointestinal drugs Takahisa Furuta
17. Pharmacogenetics of rheumatoid arthritis drugs Robert M. Plenge, Yvonne C. Lee, Souomya Raychaudhuri and Daniel H. Solomon
18. Pharmacogenomics of obstetric drugs David Haas and Jamie Renbarger
19. Pharmacogenomics of psychiatric drugs David Mrazek
20. Pharmacogenomics of pain and anesthesia drugs Evan Kharasch and Konrad Meissner
21. Pharmacogenetics of HIV and antiretroviral drugs Amalio Telenti
22. Pharmacogenomics in pediatrics Jennifer A. Lowry and J. Steven Leeder
23. Pharmacogenomics in fetal and neonatal medicine Yair Blumenfeld.
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