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Modulation of MHC Antigen Expression and Disease

$62.00 ( ) USD

Lynda G. Tussey, Andrew J. McMichael, Jiannis Ragoussis, Ian Todd, Keiko Ozato, Jenny Pan-Yun Ting, Barbara J. Vilen, D. John Maudsley, Douglas V. Faller, G. Eric Blair, Joanne L. Proffitt, Maria E. Blair Zajdel, Jennifer Bartholomew, John M. Tinsley, Peter L. Stern, Graham R. Foster, Martin Rowe, Maria G. Masucci, Jane E. Grundy, Lucy T. C. Peltenburg, Peter I. Schrier, Roger F. L. James, Ame Nouri, M. Vives-Pi, N. Somoza, F. Vargas, R. Pujol-Borrell, Fionula M. Brennan, Lionel Feigenbaum, Taduru Sreenath, Gilbert Jay
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  • Date Published: April 2011
  • availability: This ISBN is for an eBook version which is distributed on our behalf by a third party.
  • format: Adobe eBook Reader
  • isbn: 9780511888045

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About the Authors
  • The major histocompatibility complex (MHC) genes are involved in the immune system's response to tumor and infected cells and in generating an immune response. This book brings together basic aspects of the regulation of MHC antigens with important clinical applications (in viral infection, viral oncology, cancer biology and autoimmunity). There is a strong emphasis on situations where MHC expression is modulated (either stimulated or repressed). The book's major themes are: the mechanisms of MHC expression--explored at several levels including the transcription and translation of MHC genes and the insertion of MHC protein molecules into plasma membranes; the effect of cytokines on MHC expression--both in the etiology of certain diseases and in possible immunotherapeutic approaches to disease; and the use of gene therapy to modify MHC expression in cancer cells, and thereby cause tumor rejection. This book will be valuable to researchers and clinicians in molecular biology, immunology, oncology, and virology.

    • Provides an extensive basic science review of MHC expression and a series of clinical studies of altered MHC function in a single volume
    • Aimed at research scientists who need information on MHC-related diseases and clinicians who need understanding of MHC-mechanism
    • Articles written by internationally recognised team of clinicians and researchers
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    Reviews & endorsements

    "...provides a useful review of MHC molecular and cellular biology and relates these findings to viral, oncological, and autoimmune diseases...for individuals interested in MHC biology in health and in disease, this book provides a timely and up-to-date review." Alice Gottlieb, The Lancet

    "This book is a superb summary of the current understanding by some of the leading investigators." David R. Johnson, British Medical Journal

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    Product details

    • Date Published: April 2011
    • format: Adobe eBook Reader
    • isbn: 9780511888045
    • contains: 47 b/w illus. 22 tables
    • availability: This ISBN is for an eBook version which is distributed on our behalf by a third party.
  • Table of Contents

    1. General introduction to the MHC Lynda G. Tussey and Andrew J. McMichael
    2. Organisation of the MHC Jiannis Ragoussis
    3. Interactions of cytokines in the regulation of MHC class I and class II antigen expression Ian Todd
    4. Control of MHC class I gene expression Keiko Ozato
    5. Control of MHC class II gene expression Jenny Pan-Yun Ting and Barbara J. Vilen
    6. Modulation of MHC antigen expression by viruses D. John Maudsley
    7. Modulation of MHC antigen expression by retroviruses Douglas V. Faller
    8. Modulation of MHC class I antigen expression in adenovirus expression and transformation G. Eric Blair, Joanne L. Proffitt and Maria E. Blair Zajdel
    9. MHC expression in HPV-associated cervical cancer Jennifer Bartholomew, John M. Tinsley and Peter L. Stern
    10. Inhibition of the cellular response to interferon by hepatitus B virus polymerase Graham R. Foster
    11. Cellular adhesion molecules and MHC antigens in cells infected with Epstein/Barr virus: implications for immune recognition Martin Rowe and Maria G. Masucci
    12. Effect of human cytomegalovirus infection on the expression of MHC class I antigens and adhesion molecules: potential role in immune evasion and immunopathology Jane E. Grundy
    13. Oncogenes and MHC class I expression Lucy T. C. Peltenburg and Peter I. Schrier
    14. Mechanisms of tumour cell killing and the role of MHC antigens in experimental model systems Roger F. L. James
    15. Manipulation of MHC antigens by gene transfection and cytokine stimulation: a possible approach for pre-selection of suitable patients for cytokine therapy Ame Nouri
    16. Overexpression of MHC proteins in pancreatic islets: a link between cytokines, viruses, the breach of tolerance and insulin dependent diabetes mellitus? M. Vives-Pi, N. Somoza, F. Vargas and R. Pujol-Borrell
    17. The role of cytokines in contributing to MHC antigen expression in rheumatoid arthritis Fionula M. Brennan
    18. Expression of an MHC antigen in the central nervous system: an animal model for demyelinating diseases Lionel Feigenbaum, Taduru Sreenath and Gilbert Jay.

  • Editors

    G. Eric Blair, University of Leeds

    Craig R. Pringle, University of Warwick

    D. John Maudsley, University of Warwick

    Contributors

    Lynda G. Tussey, Andrew J. McMichael, Jiannis Ragoussis, Ian Todd, Keiko Ozato, Jenny Pan-Yun Ting, Barbara J. Vilen, D. John Maudsley, Douglas V. Faller, G. Eric Blair, Joanne L. Proffitt, Maria E. Blair Zajdel, Jennifer Bartholomew, John M. Tinsley, Peter L. Stern, Graham R. Foster, Martin Rowe, Maria G. Masucci, Jane E. Grundy, Lucy T. C. Peltenburg, Peter I. Schrier, Roger F. L. James, Ame Nouri, M. Vives-Pi, N. Somoza, F. Vargas, R. Pujol-Borrell, Fionula M. Brennan, Lionel Feigenbaum, Taduru Sreenath, Gilbert Jay

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