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Molecular Chaperones and Cell Signalling

$43.99 (C)

R. J. Ellis, R. S. Gupta, T. Bowes, S. Sadacharan, B. Singh, G. Chimini, A. Rubartelli, C. J. Jeffery, B. Henderson, A. Shamaei-Tousi, A. R. M. Coates, R. M. Vabulas, H. Wagner, A. Asea, S. Calderwood, M. Y. Sherman, T. Lehner, Y. Wang, T. Whittall, L A. Bergmei, A. Stephanou, D. S. Latchman, J. Frostegård, A. G. Pockley, K. Laudanski, A. De C. Miller-Graziano, V. M. Corrigal, G. S. Panayi, I. Gozes, I. Vulih, I. Spivak-Pohis, S. Furman, F. J. Quintana, I. R. Cohen, L. Mizzen, J. Neefe, P. P. Bannerjee, Z. Li, L. Hightower
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  • Date Published: March 2011
  • availability: Available
  • format: Paperback
  • isbn: 9780521177474

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About the Authors
  • This book reviews understanding of the biological roles of extracellular molecular chaperones. It provides an overview of the structure and function of molecular chaperones, their role in the cellular response to stress and their disposition within the cell. It also questions the basic paradigm of molecular chaperone biology - that these proteins are first and foremost protein-folding molecules. Paradigms of protein secretion are reviewed and the evolving concept of proteins (such as molecular chaperones) as multi-functional molecules for which the term 'moonlighting proteins' has been introduced is discussed. The role of exogenous molecular chaperones as cell regulators is examined and the physiological and pathophysiological role that molecular chaperones play is described. In the final section, the potential therapeutic use of molecular chaperones is described and the final chapter asks the question - what does the future hold for the extracellular biology of molecular chaperones?

    • Was the first book to describe the intercellular signalling functions of molecular chaperones
    • Written by specialists in molecular chaperones and by biologists interested in the signalling functions of these proteins
    • Provides full coverage of the therapeutic potential of molecular chaperones in autoimmunity, neurological disease, arthritis and cancer
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    Product details

    • Date Published: March 2011
    • format: Paperback
    • isbn: 9780521177474
    • length: 346 pages
    • dimensions: 229 x 152 x 20 mm
    • weight: 0.51kg
    • availability: Available
  • Table of Contents

    Preface
    Part I. Molecular Chaperones and the Cell Stress Response:
    1. Chaperone function: the orthodox view R. J. Ellis
    2. Intracellular disposition of mitochondrial molecular chaperones: Hsp60, mHsp70, Cpn10 and TRAP-1 R. S. Gupta, T. Bowes, S. Sadacharan and B. Singh
    Part II. Changing Paradigms of Protein Trafficking and Protein Function:
    3. Novel pathways of protein secretion G. Chimini and A. Rubartelli
    4. Moonlighting proteins: proteins with more than one function C. J. Jeffery
    5. Molecular chaperones: the unorthodox view B. Henderson and A. Shamaei-Tousi
    Part III. Molecular Chaperones as Cell Regulators:
    6. Cell-cell signalling properties of chaperonins A. R. M. Coates
    7. Toll-like receptor-dependent activation of antigen presenting cells by Hsp60, Hsp70 and Gp96 R. M. Vabulas and H. Wagner
    8. Regulation of signal transduction by intracellular and extracellular Hsp70 A. Asea and S. Calderwood
    9. Hsp72 and cell signalling M. Y. Sherman
    10. Heat shock proteins, their cell surface receptors and effect on the immune system T. Lehner, Y. Wang, T. Whittall and L. A. Bergmei
    11. Molecular chaperone-Cytokine interactions at the transcriptional level A. Stephanou and D. S. Latchman
    Part IV. Physiological and Pathophysiological Signals:
    12. Heat shock protein release and naturally-occurring exogenous heat shock proteins J. Frostegård and A. G. Pockley
    13. Hsp27 as an anti-inflammatory Protein K. Laudanski, A. De and C. Miller-Graziano
    14. Bip, a negative immune regulator involved in rheumatoid arthritis V. M. Corrigal and G. S. Panayi
    Part V. Molecular Chaperones as Therapeutics:
    15. Neuroendocrine aspects of the molecular chaperones ADNF and ADNP I. Gozes, I. Vulih, I. Spivak-Pohis and S. Furman
    16. Heat shock proteins regulate by both molecular and network cross-reactivity F. J. Quintana and I. R. Cohen
    17. Heat shock protein fusions: a platform for the induction of antigen-specific immunity L. Mizzen and J. Neefe
    18. Molecular chaperones as inducers of tumour immunity P. P. Bannerjee and Z. Li
    Part VI. What Does the Future Hold?:
    19. Gazing into the crystal ball: the unfolding future of molecular chaperones L. Hightower.

  • Editors

    Brian Henderson, University College London

    A. Graham Pockley, University of Sheffield

    Contributors

    R. J. Ellis, R. S. Gupta, T. Bowes, S. Sadacharan, B. Singh, G. Chimini, A. Rubartelli, C. J. Jeffery, B. Henderson, A. Shamaei-Tousi, A. R. M. Coates, R. M. Vabulas, H. Wagner, A. Asea, S. Calderwood, M. Y. Sherman, T. Lehner, Y. Wang, T. Whittall, L A. Bergmei, A. Stephanou, D. S. Latchman, J. Frostegård, A. G. Pockley, K. Laudanski, A. De C. Miller-Graziano, V. M. Corrigal, G. S. Panayi, I. Gozes, I. Vulih, I. Spivak-Pohis, S. Furman, F. J. Quintana, I. R. Cohen, L. Mizzen, J. Neefe, P. P. Bannerjee, Z. Li, L. Hightower

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