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Chemotherapeutic Targets in Parasites analyzes the critical metabolic reactions and structural features essential for parasite survival, and advocates the latest molecular strategies with which to identify effective antiparasitic agents. An introduction to the early development of parasite chemotherapy is followed by an overview of biophysical techniques and genomic and proteomic analysis. Several chapters are devoted to specific types of chemotherapeutic agents and their targets. There are sections discussing helminths; including metabolic, neuromuscular, microtubular and tegumental targets. The design of more selective and less toxic drugs is emphasized throughout.Read more
- Was the first comprehensive discussion in years of selective targets in parasites and effective ways to counteract them
- Book is comprehensive yet concise
- Author is well-known and extensively published
Reviews & endorsements
"Students of parasitology, research workers interested in drug development and practitioners in tropical medicine will find this book an invaluable guide to the theory of the chemical treatment of parasitic infections." Chemistry in AustraliaSee more reviews
"This publication fills a unique niche...Pharmaceutical companies and their scientists should have a ball with this set of guidelines and recommendations." Vet. Human Toxicol.
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- Date Published: August 2005
- format: Paperback
- isbn: 9780521018364
- length: 244 pages
- dimensions: 235 x 158 x 19 mm
- weight: 0.506kg
- contains: 53 b/w illus.
- availability: Available
Table of Contents
1. The search for antiparasitic agents
2. Biophysical, genomic, and proteomic analysis of drug targets
3. Energy metabolism in parasitic helminths: targets for antiparasitic agents
4. Antimalarial agents and their targets
5. Antitrypanosomal and antileishmanial targets
6. Targets in amitochondrial protists
7. Neuromuscular structures and microtubules as targets
8. Targets in the teguments of flatworms
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