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Anesthetic Pharmacology
Basic Principles and Clinical Practice
2 Part Hardback Set

2nd Edition

$295.00 (G)

Stuart A. Forman, Marcel E. Durieux, Istvan Nagy, Isobel Lever, Mario Cibelli, Thomas McDowell, Misha Perouansky, Robert A. Pearce, Thomas W. Schnider, Charles F. Minto, Evan D. Kharasch, Roland Bainton, Michel M. R. F. Struys, Tom De Smet, Ola Dale, Kirk Hogan, Talmage D. Egan, Charles Minto, Alex Macario, George A. Mashour, Max Kelz, M. B. MacIver, Robert Veselis, Rob W. Gereau IV, Laura F. Cavallone, Gary R. Strichartz, Joe Henry Steinbach, Ling-Gang Wu, Walter A. Boyle, Isao Tsuneyoshi, Brian S. Donahue, Jeffrey R. Balser, Pierre Foex, Helen Higham, Jonathan Moss, David Glick, Nigel R. Webster, Helen F. Galley, Mike Crowder, Alex S. Evers, Geoff Lockwood, Thomas J. Ebert, Larry Lindenbaum, Frederique Servin, John W. Sear, Frances Davies, Uwe Rudolph, Juliana Barr, Rob Sanders, Mervyn Maze, Michael Schäefer, Danesh K. Gupta, Tom C. Krejcie, Michael J. Avram, Carl E. Rosow, Mark Dershwitz, Nilesh Randive, Richard Langford, Mark A. Schumacher, Helge Eilers, Francis V. Salinas, David B. Auyong, W. Andrew Kofke, Heidrun Fink, Manfred Blobne, J. A. Jeevendra Martyn, Mohammed Naguib, David F. Stowe, Tom J. Ebert, Berent Mets, Imre Redai, Andrew J. Patterson, Aman Mahajan, Charles W. Hogue Jr, Paul S. Pagel, David C. Warltier, Roger A. Johns, Stephen Yang, W. Scott Beattie, Charles W. Emala, Sunita Sastry, Ronald G. Pearl, Dean R. Jones, H. T. Lee, Robert G. Hahn, Clifford S. Deutschman, Nándor Marczin, Kristof Racz, Robert Walt, E. B. Campbell, Jens Scholz, Markus Steinfath, Patrick Meybohm, Nick Oliver, Martin Smith, Stephen Robinson, Paul Wischmeyer, Troy Wildes, Michael Avidan, George Despotis, Tony Gin, Conan MacDougall, B. Joseph Guglielmo, Jeanine Wiener-Kronish, Laureen Hill, T. Andrew Bowdle, J. Lance Lichtor, Christopher G. Hughes, Stuart McGrane, E. Wesley Ely, Pratik P. Pandaharipande, Richard W. Rosenquist, Ellen W. King, Arthur Wallace, Eric Jacobsohn, Waiel Almoustadi, Chinniampalayam Rajamohan, Howard B. Gutstein, Jerrold H. Levy, Greg B. Hammer, Brian J. Anderson, Jeff Silverstein, Brian P. Head, Piyush Patel
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  • Date Published: April 2011
  • availability: Available
  • format: Multiple copy pack
  • isbn: 9780521896665

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About the Authors
  • In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, second edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period.

    • Exhaustive: covers all the key pharmacologic and physiologic information on how each drug works at a molecular, cellular and organ level
    • Practical: gives all the important drug information an anesthetist needs - dose ranges, interactions with other drugs, toxicity, use in different patient groups
    • Relevant: the new section on Therapeutics of Clinical Practice tells the anesthetist how to select and use the right drugs in a wide range of day-to-day clinical scenarios
    Read more

    Reviews & endorsements

    'Despite being titled as a pharmacology text, there is significant coverage of the pathophysiology and practice of anaesthesia. The content is current, with several new drug compounds and theories of action described. This book complements the filtered down information found in many of the smaller texts recommended to trainees sitting exams and by increasing understanding of the subjects might aid long-term learning … It provides an enormous amount of information to the reader in a clear and understandable format. As a reference text, it would be a bood addition to the library of an anaesthesiaor intensive care department.' The Journal of Anaesthesia

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    Product details

    • Edition: 2nd Edition
    • Date Published: April 2011
    • format: Multiple copy pack
    • isbn: 9780521896665
    • length: 1262 pages
    • dimensions: 283 x 225 x 63 mm
    • weight: 4.5kg
    • contains: 200 b/w illus. 190 colour illus. 137 tables
    • availability: Available
  • Table of Contents

    Preface to the first edition
    Preface to the second edition
    Part I. Principles of Drug Action:
    1. Pharmacodynamic principles of drug action
    2. G protein coupled receptors
    3. Other signalling pathways
    4. Signal transduction mechanisms: ion channels
    5. Principles of pharmacokinetics
    6. Principles of drug transformation
    7. Drug transport and transporters
    8. Target controlled infusions and closed loop administration
    9. Alternate routes of drug administration
    10. Principles of pharmacogenetics
    11. Pharmacodynamic drug interactions in anesthetic practice
    12. Pharmacoeconomics
    Part II. Physiologic Substrates of Drug Action:
    13. Sleep and consciousness
    14. Synaptic transmission
    15. Memory, learning and cognition
    16. Mechanisms of pain transmission and transduction
    17. Generation and propagation of action potentials
    18. Neuromuscular junction
    19. Vascular reactivity
    20. Cardiac rhythm
    21. Myocardial performance
    22. Autonomic function
    23. Physiology of immunity and inflammation
    Part III. Essential Drugs in Anesthetic Practice:
    24. Mechanisms of anesthetic action
    25. Pharmacokinetics of inhaled anesthetics
    26. Clinical pharmacology of inhaled anesthetics
    27. Pharmacokinetics of intravenous anesthetics
    28. Clinical pharmacology of intravenous anesthetics
    29. Benzodiazepines
    30. α-2 Agonists and other sedatives and amnestics
    31. Mechanisms of action of opioids
    32. Pharmacokinetics of opioids
    33. Clinical pharmacology of opioids
    34. Nonsteroidal anti-inflammatory drugs
    35. Other ion channel and receptor ligands for analgesia
    36. Local anesthetics
    37. Anticonvulsant and antipsychotic drugs
    38. Neuromuscular blocking agents
    39. Reversal drugs
    40. Sympathomimetics and vasoconstrictors
    41. Parasympathomimetic and parasympatholytic drugs
    42. β-blockers and other adrenergic receptor antagonists
    43. Antiarrhythmic agents
    44. Positive inotropic drugs
    45. Vasodilators (incl. ACE inhibitors and NO)
    46. Calcium channel blockers
    47. Bronchodilators
    48. Pulmonary vasodilators
    49. Drugs acting via the kidney
    50. Fluids and electrolytes as pharmacologic agents
    51. Corticosteroids and anti-inflammatory agents
    52. Anti-rejection drugs and immunosuppressants
    53. Antimotility and antisecretory agents
    54. Antiemetics
    55. Insulin and anti-hyperglycemic agents
    56. Nutritional elements of management
    57. Agents affecting coagulation and platelet function
    58. Obstetrical adjuvants and obstetric pharmacology
    59. Antimicrobial therapy
    Part IV. Clinical Application and Anesthesia Practice (Evidence Based, Rational Drug Selection, Management):
    60. Pre-operative management
    61. Induction of anesthesia
    62. Maintenance and emergence from anesthesia
    63. Management of sedation, analgesia and delirium
    64. Post-operative analgesia
    65. Control of blood pressure and vascular tone
    66. Cardiac protection and pharmacologic management of myocardial ischemia
    67. Management of patients with chronic alcohol or drug use
    68. Drug allergy and treatment
    69. Special populations - pediatric
    70. Special populations - geriatric
    71. Emerging concepts: neuroprotection and neurotoxicity
    Index.

  • Editors

    Alex S. Evers, Washington University School of Medicine, St Louis
    Alex S. Evers is Henry E. Mallinckrodt Professor of Anesthesiology, and Professor of Internal Medicine and Molecular Biology and Pharmacology, Washington University School of Medicine, USA.

    Mervyn Maze, University of California, San Francisco
    Professor Mervyn Maze is Chair, Department of Anesthesia and Perioperative Care, University of California, San Francisco, USA.

    Evan D. Kharasch, Washington University School of Medicine, St Louis
    Evan Kharasch is Russell D. and Mary B. Shelden Professor of Anesthesiology, Director, Division of Clinical and Translational Research, Department of Anesthesiology, and Professor of Biochemistry and Molecular Biophysics, Washington University, USA.

    Contributors

    Stuart A. Forman, Marcel E. Durieux, Istvan Nagy, Isobel Lever, Mario Cibelli, Thomas McDowell, Misha Perouansky, Robert A. Pearce, Thomas W. Schnider, Charles F. Minto, Evan D. Kharasch, Roland Bainton, Michel M. R. F. Struys, Tom De Smet, Ola Dale, Kirk Hogan, Talmage D. Egan, Charles Minto, Alex Macario, George A. Mashour, Max Kelz, M. B. MacIver, Robert Veselis, Rob W. Gereau IV, Laura F. Cavallone, Gary R. Strichartz, Joe Henry Steinbach, Ling-Gang Wu, Walter A. Boyle, Isao Tsuneyoshi, Brian S. Donahue, Jeffrey R. Balser, Pierre Foex, Helen Higham, Jonathan Moss, David Glick, Nigel R. Webster, Helen F. Galley, Mike Crowder, Alex S. Evers, Geoff Lockwood, Thomas J. Ebert, Larry Lindenbaum, Frederique Servin, John W. Sear, Frances Davies, Uwe Rudolph, Juliana Barr, Rob Sanders, Mervyn Maze, Michael Schäefer, Danesh K. Gupta, Tom C. Krejcie, Michael J. Avram, Carl E. Rosow, Mark Dershwitz, Nilesh Randive, Richard Langford, Mark A. Schumacher, Helge Eilers, Francis V. Salinas, David B. Auyong, W. Andrew Kofke, Heidrun Fink, Manfred Blobne, J. A. Jeevendra Martyn, Mohammed Naguib, David F. Stowe, Tom J. Ebert, Berent Mets, Imre Redai, Andrew J. Patterson, Aman Mahajan, Charles W. Hogue Jr, Paul S. Pagel, David C. Warltier, Roger A. Johns, Stephen Yang, W. Scott Beattie, Charles W. Emala, Sunita Sastry, Ronald G. Pearl, Dean R. Jones, H. T. Lee, Robert G. Hahn, Clifford S. Deutschman, Nándor Marczin, Kristof Racz, Robert Walt, E. B. Campbell, Jens Scholz, Markus Steinfath, Patrick Meybohm, Nick Oliver, Martin Smith, Stephen Robinson, Paul Wischmeyer, Troy Wildes, Michael Avidan, George Despotis, Tony Gin, Conan MacDougall, B. Joseph Guglielmo, Jeanine Wiener-Kronish, Laureen Hill, T. Andrew Bowdle, J. Lance Lichtor, Christopher G. Hughes, Stuart McGrane, E. Wesley Ely, Pratik P. Pandaharipande, Richard W. Rosenquist, Ellen W. King, Arthur Wallace, Eric Jacobsohn, Waiel Almoustadi, Chinniampalayam Rajamohan, Howard B. Gutstein, Jerrold H. Levy, Greg B. Hammer, Brian J. Anderson, Jeff Silverstein, Brian P. Head, Piyush Patel

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