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Look Inside Genomic Imprinting

Genomic Imprinting
Causes and Consequences

$58.00 (G)

  • Editors:
  • R. Ohlsson, Uppsala universitet, Sweden
  • K. Hall, Karolinska Institutet, Stockholm
  • M. Ritzen, Karolinska Institutet, Stockholm
A. Gilligan, D. Solter, D. Haig, R. Trivers, J. Forejt, S. Gregorovà, M. Landíková, J. Capková, L. M. Silver, A. P. Wolffe, P. B. Singh, T. C. James, T. H. Bestor, R. Jaenisch, C. Beard, E. Li, M. F. Lyon, M. A. Surani, A. C. Ferguson-Smith, H. Sasaki, S. C. Barton, W. Reik, R. Feil, N. D. Allen, T. F. Moore, J. Walter, S. M. Tilgham, M. S. Bartolomei, A. L. Webber, M. E. Brunkow, J. Saam, P. A. Leighton, K. Pfeifer, R. Ohlsson, T. Ekström, G. Franklin, S. Pfeifer-Ohlsson, H. Cui, S. Miller, R. Fisher, C. Walsh, I. Simon, H. Cedar, A. E. Reeve, M. Mannens, R. Weksberg, J. Squire, G. B. Côté, B. Tycko, A. P. Feinberg, B. Horsthemke, B. Dittrich, K. Buiting, U. Francke, J. A. Kerns, J. Giacalone, B. M. Cattanach, J. Barr, J. Jones, T. Mukai, I. Hatada, T. Yamaoka, K. Kitagawa, X.-D. Wang, T. Sugama, J. Masuda, J. Ogata, D. P. Barlow
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  • Date Published: February 2011
  • availability: Available
  • format: Paperback
  • isbn: 9780521179997

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About the Authors
  • Genomic imprinting results in the preferential expression of one gene, depending on the parent of origin, and it is associated with several disease syndromes in humans. This book covers a wealth of research material on chromatin structure, epigenetics, clinical genetics, developmental biology, cancer, hypotheses of evolution, and the molecular basis of the imprinting process, which will help explain not only the mechanisms of genomic imprinting, but also its biological and medical consequences.

    • Sponsored by the prestigious Nobel foundation
    • Internationally recognised team of contributors
    • Burgeoning area of research
    Read more

    Reviews & endorsements

    "The names of most of the contributors will be familiar to those who have followed the field, as will the subject matter of most of the papers. But this is unlikely to prevent the vast majority of readers from encountering a number of pleasant surprises...a major strength of this collection, for the student and the casually interested reader, is in the way the majority of contributors have summarized the results of many experiments in a few sentences...The conversational tone of the contributions further makes for entertaining reading." Carmen Sapienza, Science

    "The 24 contributed chapters have considerable scope...a useful resource not only for those actually working in the area, but also for those who are not working in this field but who need to maintain some level of knowledge for educational purposes." Roger W. Melvold, Doody's Health Sciences Book Review Journal

    "...a valuable resource....It should be useful to scientists new to the field and to those wanting a broad view of the various imprinted systems....the information and models that it contains will continue to guide research in this dynamic field." Fay L. Shamanski, American Journal of Human Genetics

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    Product details

    • Date Published: February 2011
    • format: Paperback
    • isbn: 9780521179997
    • length: 396 pages
    • dimensions: 244 x 170 x 21 mm
    • weight: 0.63kg
    • availability: Available
  • Table of Contents

    Contributors
    Part I. Genomic Imprinting in Mammals:
    1. The role of imprinting in early mammalian development A. Gilligan, and D. Solter
    2. The evolution of parental imprinting: a review of hypotheses D. Haig and R. Trivers
    3. Genetic variations in parental imprinting on mouse chromosome 17 J. Forejt, S. Gregorovà, M. Landíková, J. Capková and L. M. Silver
    Part II. Chromatin Structure and DNA Modifications:
    4. Epigenetic inheritance: the chromatin connection A. P. Wolffe
    5. Chromobox genes and the molecular mechanisms of cellular determination P. B. Singh and T. C. James
    6. The biochemical basis of allele-specific gene expression in genomic imprinting and X inactivation T. H. Bestor
    7. DNA methylation and mammalian development R. Jaenisch, C. Beard and E. Li
    Part III. Mechanisms of Imprinting:
    8. X chromosome inactivation and imprinting M. F. Lyon
    9. Imprinting of H19 and Xist in uniparental embryos M. A. Surani, A. C. Ferguson-Smith, H. Sasaki and S. C. Barton
    10. Imprinted genes, allelic methylation, and imprinted modifiers of methylation W. Reik, R. Feil, N. D. Allen, T. F. Moore and J. Walter
    11. Genomic imprinting of the H19 and Igf2 genes in the mouse S. M. Tilgham, M. S. Bartolomei, A. L. Webber, M. E. Brunkow, J. Saam, P. A. Leighton and K. Pfeifer
    12. Plasticity of imprinting R. Ohlsson, T. Ekström, G. Franklin, S. Pfeifer-Ohlsson, H. Cui, S. Miller, R. Fisher and C. Walsh
    13. Regional regulation of allele-specific gene expression I. Simon and H. Cedar
    Part IV. Genomic Imprinting in Embryonal Tumors and Overgrowth Disorders:
    14. Genomic imprinting in embryonal tumors and overgrowth disorders A. E. Reeve
    15. Tracking imprinting: the Beckwith-Wiedemann syndrome M. Mannens
    16. Genomic imprinting in Beckwith-Wiedemann syndrome R. Weksberg and J. Squire
    17. Mitotic crossing over and the disruption of genomic imprinting G. B. Côté
    18. Evaluating H19 as an imprinted tumor suppressor gene B. Tycko
    19. A domain of abnormal imprinting in human cancer A. P. Feinberg
    Part V. Genomic Imprinting and the Prader-Willi Syndrome:
    20. Parent-of-origin-specific DNA methylation and imprinting mutations on human chromosome 15 B. Horsthemke, B. Dittrich and K. Buiting
    21. The SNRPN gene and Prader-Willi syndrome U. Francke, J. A. Kerns and J. Giacalone
    Part VI. Imprinting: A Search for New Genes and Unifying Principles:
    22. Use of chromosome rearrangements for investigations into imprinting in the mouse B. M. Cattanach, J. Barr and J. Jones
    23. A new imprinted gene, U2af-related sequence, isolated by a methylation-sensitive genome scanning method T. Mukai, I. Hatada, T. Yamaoka, K. Kitagawa, X.-D. Wang, T. Sugama, J. Masuda and J. Ogata
    24. The mouse Igf2/MPR gene: a model for all gametic imprinted genes? D. P. Barlow
    Index.

  • Editors

    R. Ohlsson, Uppsala universitet, Sweden

    K. Hall, Karolinska Institutet, Stockholm

    M. Ritzen, Karolinska Institutet, Stockholm

    Contributors

    A. Gilligan, D. Solter, D. Haig, R. Trivers, J. Forejt, S. Gregorovà, M. Landíková, J. Capková, L. M. Silver, A. P. Wolffe, P. B. Singh, T. C. James, T. H. Bestor, R. Jaenisch, C. Beard, E. Li, M. F. Lyon, M. A. Surani, A. C. Ferguson-Smith, H. Sasaki, S. C. Barton, W. Reik, R. Feil, N. D. Allen, T. F. Moore, J. Walter, S. M. Tilgham, M. S. Bartolomei, A. L. Webber, M. E. Brunkow, J. Saam, P. A. Leighton, K. Pfeifer, R. Ohlsson, T. Ekström, G. Franklin, S. Pfeifer-Ohlsson, H. Cui, S. Miller, R. Fisher, C. Walsh, I. Simon, H. Cedar, A. E. Reeve, M. Mannens, R. Weksberg, J. Squire, G. B. Côté, B. Tycko, A. P. Feinberg, B. Horsthemke, B. Dittrich, K. Buiting, U. Francke, J. A. Kerns, J. Giacalone, B. M. Cattanach, J. Barr, J. Jones, T. Mukai, I. Hatada, T. Yamaoka, K. Kitagawa, X.-D. Wang, T. Sugama, J. Masuda, J. Ogata, D. P. Barlow

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