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Drug Resistance in Cancer

Drug Resistance in Cancer
Mechanisms and Models

$252.00 (G)

  • Date Published: November 1998
  • availability: Available
  • format: Hardback
  • isbn: 9780521482738

$ 252.00 (G)
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About the Authors
  • Drug resistance in cancer, whereby a portion of cancer cells evades chemotherapy, poses a profound and continuing challenge for the effective treatment of cancer. The principles underlying the biological mechanisms behind this phenomenon are clearly explained in this volume. A deeper understanding of drug resistance requires a quantitative appreciation of the dynamic forces that shape tumor growth, including spontaneous mutation and selection processes. The authors seek to explain and to simplify these complex mechanisms, and to place them in a clinical context. Clearly explained mathematical models are used to illustrate the biological principles and provide an insight into tumor development and the effectiveness and limitations of drug treatment. The volume is suitable for those with a nonmathematical background and aims to enhance the effectiveness of cancer therapy. This is the first book to provide such an integrated account, in a form accessible to both doctor and scientist.

    Reviews & endorsements

    'However, this volume provides a very good overview of the drug resistance field with special emphasis on mathematical models and can be recommended to everyone interested in the field. Even those who see math as an alien subject will find this book useful, since the mathematical portions of the text have been kept as straightforward as possible. The book is a good source of references and suggestions for further reading and should interest a wide readership including clinicians, molecular biologists, and researchers interested in tumor growth, tumor killing and mutation models.' V. Spataro, Annals of Oncology

    '… required reading for all trainees in oncology.' Paul P. Carbone, Oncology

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    Product details

    • Date Published: November 1998
    • format: Hardback
    • isbn: 9780521482738
    • length: 256 pages
    • dimensions: 229 x 152 x 19 mm
    • weight: 0.5kg
    • contains: 22 b/w illus. 6 tables
    • availability: Available
  • Table of Contents

    Preface
    1. The biological basis of cancer and the problem of drug resistance
    2. Tumour growth, stem cells and experimental chemotherapy
    3. Molecular aspects of drug resistance
    4. Quantitative descriptions of the origins of drug resistance
    5. Development and exploration of the random mutation model for drug resistance
    6. Extensions of the random mutation model for drug resistance
    7. Clinical predictions of the random mutation model
    8. Directed versus random mutation and the problem of intrinsic resistance
    9. Some final thoughts on the problem of drug resistance
    Index.

  • Authors

    James H. Goldie, University of British Columbia, Vancouver

    Andrew J. Coldman, University of British Columbia, Vancouver

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