Skip to content
Register Sign in Wishlist
Drug Resistance in Cancer

Drug Resistance in Cancer
Mechanisms and Models

$252.00 (G)

  • Date Published: November 1998
  • availability: Available
  • format: Hardback
  • isbn: 9780521482738

$ 252.00 (G)

Add to cart Add to wishlist

Other available formats:
Paperback, eBook

Looking for an examination copy?

If you are interested in the title for your course we can consider offering an examination copy. To register your interest please contact providing details of the course you are teaching.

Product filter button
About the Authors
  • Drug resistance in cancer, whereby a portion of cancer cells evades chemotherapy, poses a profound and continuing challenge for the effective treatment of cancer. The principles underlying the biological mechanisms behind this phenomenon are clearly explained in this volume. A deeper understanding of drug resistance requires a quantitative appreciation of the dynamic forces that shape tumor growth, including spontaneous mutation and selection processes. The authors seek to explain and to simplify these complex mechanisms, and to place them in a clinical context. Clearly explained mathematical models are used to illustrate the biological principles and provide an insight into tumor development and the effectiveness and limitations of drug treatment. The volume is suitable for those with a nonmathematical background and aims to enhance the effectiveness of cancer therapy. This is the first book to provide such an integrated account, in a form accessible to both doctor and scientist.

    Reviews & endorsements

    'However, this volume provides a very good overview of the drug resistance field with special emphasis on mathematical models and can be recommended to everyone interested in the field. Even those who see math as an alien subject will find this book useful, since the mathematical portions of the text have been kept as straightforward as possible. The book is a good source of references and suggestions for further reading and should interest a wide readership including clinicians, molecular biologists, and researchers interested in tumor growth, tumor killing and mutation models.' V. Spataro, Annals of Oncology

    '… required reading for all trainees in oncology.' Paul P. Carbone, Oncology

    See more reviews

    Customer reviews

    Not yet reviewed

    Be the first to review

    Review was not posted due to profanity


    , create a review

    (If you're not , sign out)

    Please enter the right captcha value
    Please enter a star rating.
    Your review must be a minimum of 12 words.

    How do you rate this item?


    Product details

    • Date Published: November 1998
    • format: Hardback
    • isbn: 9780521482738
    • length: 256 pages
    • dimensions: 229 x 152 x 19 mm
    • weight: 0.5kg
    • contains: 22 b/w illus. 6 tables
    • availability: Available
  • Table of Contents

    1. The biological basis of cancer and the problem of drug resistance
    2. Tumour growth, stem cells and experimental chemotherapy
    3. Molecular aspects of drug resistance
    4. Quantitative descriptions of the origins of drug resistance
    5. Development and exploration of the random mutation model for drug resistance
    6. Extensions of the random mutation model for drug resistance
    7. Clinical predictions of the random mutation model
    8. Directed versus random mutation and the problem of intrinsic resistance
    9. Some final thoughts on the problem of drug resistance

  • Authors

    James H. Goldie, University of British Columbia, Vancouver

    Andrew J. Coldman, University of British Columbia, Vancouver

Sign In

Please sign in to access your account


Not already registered? Create an account now. ×

Sorry, this resource is locked

Please register or sign in to request access. If you are having problems accessing these resources please email

Register Sign in
Please note that this file is password protected. You will be asked to input your password on the next screen.

» Proceed

You are now leaving the Cambridge University Press website. Your eBook purchase and download will be completed by our partner Please see the permission section of the catalogue page for details of the print & copy limits on our eBooks.

Continue ×

Continue ×

Continue ×

Find content that relates to you

Join us online

This site uses cookies to improve your experience. Read more Close

Are you sure you want to delete your account?

This cannot be undone.


Thank you for your feedback which will help us improve our service.

If you requested a response, we will make sure to get back to you shortly.

Please fill in the required fields in your feedback submission.