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Bacterial Protein Toxins
Role in the Interference with Cell Growth Regulation

£31.99

Part of Advances in Molecular and Cellular Microbiology

Alistair J. Lax, Gillian D Pullinger, Gudula Schmidt, Klaus Aktories, Bernard Ducommun, Jean de Rycke, Garret Ihler, Anita Verma, Javier Arevalo, Luís J. Mota, Guy R Cornelis, Neil W. A. McGowan, Dympna Harmey, Fraser P. Coxon, Gudrun Stenbeck, Michael J. Rogers, Agamemnon E Grigoriadis, Michael Naumann, Jean E. Crabtree, Christine P. J. Caygill, Michael J. Hill
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  • Date Published: April 2011
  • availability: Available
  • format: Paperback
  • isbn: 9780521177467

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  • Bacterial toxins that act inside cells interact very specifically with key components of the cell and some even manipulate the cell in subtle ways for their own purposes. These potent toxins, described in this 2005 book, will be of interest to both microbiologists and cell biologists. Some of these toxins are conventional multidomain toxins that are self-programmed to enter cells. Others are delivered by type III mechanisms, often as a package of potent molecules. The molecular targets for all these toxins mediate signal transduction and the cell cycle to regulate the crucial processes of cell growth, cell division and differentiation. Thus these potent toxins are not only responsible for disease, but also provide a powerful set of tools with which to interrogate the biology of the cell. In addition such toxins may act directly to promote carcinogenesis and hence their study is also of interest in a wider context.

    • Was the first book specifically on toxins that interfere with growth regulation
    • Relevance to microbiologists and cell biologists
    • Written by experts in the field
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    Product details

    • Date Published: April 2011
    • format: Paperback
    • isbn: 9780521177467
    • length: 258 pages
    • dimensions: 229 x 152 x 15 mm
    • weight: 0.38kg
    • availability: Available
  • Table of Contents

    1. Toxins and the interaction between bacterium and host Alistair J. Lax
    2. The mitogenic Pasteurella multocida toxin and cellular signalling Gillian D. Pullinger
    3. Rho-activating toxins and growth regulation Gudula Schmidt and Klaus Aktories
    4. Cytolethal distending toxins: a paradigm for bacterial cyclostatins Bernard Ducommun and Jean de Rycke
    5. Bartonella signaling and endothelial cell proliferation Garret Ihler, Anita Verma and Javier Arevalo
    6. Type III delivered toxins that target signaling pathways Luís J. Mota and Guy R. Cornelis
    7. Bacterial toxins and bone remodelling Neil W. A. McGowan, Dympna Harmey, Fraser P. Coxon, Gudrun Stenbeck, Michael J. Rogers and Agamemnon E Grigoriadis
    8. Helicobacter pylori-mechanisms for inducing epithelial cell proliferation Michael Naumann and Jean E. Crabtree
    9. Bacteria and cancer Christine P. J. Caygill and Michael J. Hill
    10. What is there still to learn about bacterial toxins? Alistair J. Lax.

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    Bacterial Protein Toxins

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  • Editor

    Alistair J. Lax, King's College London

    Contributors

    Alistair J. Lax, Gillian D Pullinger, Gudula Schmidt, Klaus Aktories, Bernard Ducommun, Jean de Rycke, Garret Ihler, Anita Verma, Javier Arevalo, Luís J. Mota, Guy R Cornelis, Neil W. A. McGowan, Dympna Harmey, Fraser P. Coxon, Gudrun Stenbeck, Michael J. Rogers, Agamemnon E Grigoriadis, Michael Naumann, Jean E. Crabtree, Christine P. J. Caygill, Michael J. Hill

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