DNA Microarrays and Gene Expression
From Experiments to Data Analysis and Modeling
- Pierre Baldi, University of California, Irvine
- G. Wesley Hatfield, University of California, Irvine
Massive data acquisition technologies, such as genome sequencing, high-throughput drug screening, and DNA arrays are in the process of revolutionizing biology and medicine. Using the mRNA of a given cell, at a given time, under a given set of conditions, DNA microarrays can provide a snapshot of the level of expression of all the genes in the cell. Such snapshots can be used to study fundamental biological phenomena such as development or evolution, to determine the function of new genes, to infer the role individual genes or groups of genes may play in diseases, and to monitor the effect of drugs and other compounds on gene expression. Originally published in 2002, this inter-disciplinary introduction to DNA arrays will be of value to anyone with an a interest in this powerful technology.Read more
- Concise, user-friendly overview of this revolutionary new technology
- Co-authored by a computer scientist and biologist to give a unique, inter-disciplinary introduction to this fast-moving field
- An accessible introduction for both the biology and computer science communities
Reviews & endorsements
Review of the hardback: 'The book, written by Baldi and Hatfield, is an important and timely addition to the DNA microarray literature … the first several chapters of the book provide an easy-to-digest overview of the current state of DNA microarrays.' Briefings in Functional Genomics & ProteomicsSee more reviews
Review of the hardback: 'Writing a book such as this was a challenging remit and one that the authors have achieved with great success.' Human Genomics
Review of the hardback: 'I recommend very highly this book to statisticians in particular.' Journal of Statistical Computation & Simulation
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- Date Published: December 2004
- format: Adobe eBook Reader
- isbn: 9780511056888
- availability: This ISBN is for an eBook version which is distributed on our behalf by a third party.
Table of Contents
1. A brief history of genomics
2. DNA array formats
3. DNA array readout methods
4. Gene expression profiling experiments: problems, pitfalls and solutions
5. Statistical analysis of array data: inferring changes
6. Statistical analysis of array data: dimensionality reduction, clustering, and regulatory regions
7. Survey of current DNA array applications
8. Systems biology: overview of regulatory, metabolic and signaling networks.
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