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Cybernetic Modeling for Bioreaction Engineering


Part of Cambridge Series in Chemical Engineering

  • Date Published: October 2018
  • availability: In stock
  • format: Hardback
  • isbn: 9781107000520

£ 105.00

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About the Authors
  • Uniquely focusing on dynamic modeling, this volume incorporates metabolic regulation as a survival mechanism for cells, by driving metabolism through optimal investment of its resources for control of enzyme synthesis and activity. Consequently, the models have a proven record of describing various uptake patterns of mixed carbon substrates that have become significant in modern applications of biomass for the production of bioenergy. The models accurately describe dynamic behavior of microbes in nutrient environments with mixtures of complementary substrates, such as carbon and nitrogen. Modeling of large metabolic networks (including prospects for extension to genome scale) is enabled by lumped hybrid cybernetic models with an unparalleled capacity to predict dynamic behavior of knockout strains. This is an invaluable, must-have reference for bio-researchers and practicing engineers.

    • Offers a dynamic look at metabolism, focusing on productivity as well as yield of metabolic products
    • Provides a comprehensive account of metabolic regulation, offering more reliable control and optimization of bioprocesses
    • Lays the groundwork for dynamic genome scale analysis
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    Product details

    • Date Published: October 2018
    • format: Hardback
    • isbn: 9781107000520
    • length: 294 pages
    • dimensions: 253 x 179 x 17 mm
    • weight: 0.74kg
    • contains: 143 b/w illus.
    • availability: In stock
  • Table of Contents

    1. Introduction
    2. Enzymatic adaptation
    3. Early development of cybernetic models
    4. Revisiting cybernetic laws via optimal control theory
    5. Towards modeling of metabolic networks
    6. The hybrid cybernetic model (HCM)
    7. The lumped hybrid cybernetic model (L-HCM)
    8. Predicting dynamic behavior of mutant strains with L-HCM
    9. Nonlinear analysis of cybernetic models
    10. Metabolic modeling landscape

  • Authors

    Doraiswami Ramkrishna, Purdue University, Indiana
    Doraiswami Ramkrishna is the Harry Creighton Peffer Distinguished Professor of Chemical Engineering at Purdue University, Indiana. He pioneered the development of dynamic metabolic modeling, and has been active in the area for over thirty years. He is a member of the National Academy of Engineering, coined the term 'cybernetic modeling', and has authored several academic books.

    Hyun-Seob Song, Pacific Northwest National Laboratory, Washington
    Hyun-Seob Song is a Senior Research Scientist at Pacific Northwest National Laboratory, Washington (PNNL). His new development of metabolic pathway analysis enabled dynamic metabolic modeling for complex, large-scale networks. He is also active in the areas of network inference and microbial community modeling.

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