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Fever and Antipyresis
The Role of the Nervous System

$50.00 USD

  • Date Published: February 2011
  • availability: This ISBN is for an eBook version which is distributed on our behalf by a third party.
  • format: Adobe eBook Reader
  • isbn: 9780511833519

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  • This book provides a detailed overview of the function of the nervous system in fever and its role in antipyresis. The volume opens with an introductory account of fever, its physiology and adaptive role, and explains the mechanisms of thermoregulation. Sufficient information about bacterial pyrogens, 'endogenous' pyrogenic cytokines, body temperature regulation and survival value of fever and its ubiquity is given to enable readers to follow the central nervous system's involvement. The book should enable graduate students and researchers in neuroscience and other disciplines to understand the impact of their studies in the overall processes of fever. It will also be of benefit to pharmacologists studying anti-pyretics and the central nervous system function of these drugs. Academic clinicians will find this a more comprehensive overview of fever than other available texts. Finally, the author challenges some well-established dogmas in this area and sets an agenda for future research.

    • A more comprehensive overview of fever mechanisms than is presently available
    • Questions many dogmatic statements appearing in textbooks
    • Supplements and integrates a wide range of material which is presently widely dispersed in the scientific literature
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    Product details

    • Date Published: February 2011
    • format: Adobe eBook Reader
    • isbn: 9780511833519
    • contains: 45 b/w illus. 7 tables
    • availability: This ISBN is for an eBook version which is distributed on our behalf by a third party.
  • Table of Contents

    Preface
    1. Fever – definition, usefulness, ubiquity
    2. Thermoregulation – an outline
    3. The nature of pyrogens, their origins and mode of release
    4. The loci of action of endogenous mediators of fever
    5. Beyond the loci of action of circulating pyrogens: mediators and mechanisms
    6. The role of the cerebral cortex, the limbic system, peripheral nervous system and spinal cord, and induced changes in intracranial pressure
    7. Antipyresis
    8. Febrile convulsions in children and a possible role for vasopressin
    9. A synthesis, predictions and speculation from my armchair
    Appendix 1: Anatomical considerations
    References
    Index.

  • Author

    Keith E. Cooper, University of Calgary

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