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In Vitro Methods in Toxicology

$48.00 USD

G. B. Leslie, P. Johnson, M. A. Snith, W. R. Hewitt, J. Hook, E. S. Harpur, N. Sperelakis, G. Bkaily, A. Cockburn, C. K. Atterwill, C. G. Brown, A. Poole, R. C. Brown, R. J. Chenery, J. S. H. Luke, G. R. Betton, R. S. Lawrence, P. A. Duffy, O. P. Flint, M. Richold, K. Miller, S. Nicklin, S. G. Volsen, D. L. Cockroft, C. E. Steele, S. J. Freeman, N. A. Brown, D. A. Garside, P. McKibbin,
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  • Date Published: May 2012
  • availability: This ISBN is for an eBook version which is distributed on our behalf by a third party.
  • format: Adobe eBook Reader
  • isbn: 9781139245364

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  • First published in 1987, this book describes tissue (cell and organ) culture techniques which could be used at a critical predevelopment stage to screen for drug-inducing toxicity or to analyse the molecular mechanisms of toxicity at a later stage in parallel with investigative studies. This type of research has important ethical, financial and scientific implications. In particular, less animals and compound are required in in vitro research and more detailed information at the cellular and subcellular levels can be obtained. The volume brings together the once disparate knowledge of cultural techniques and thus provides an important reference work for industrial and academic toxicologists. It could also form a framework for discussion of potential improvements and modification of toxicity testing.

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    Product details

    • Date Published: May 2012
    • format: Adobe eBook Reader
    • isbn: 9781139245364
    • availability: This ISBN is for an eBook version which is distributed on our behalf by a third party.
  • Table of Contents

    Introduction G. B. Leslie and P. Johnson
    Part I. Target Organ Toxicity:
    1. In vitro methods in renal toxicology M. A. Snith, W. R. Hewitt and J. Hook
    2. Ototoxicity E. S. Harpur
    3. Cultured cell models for studying problems in cardiac toxicology N. Sperelakis and G. Bkaily
    4. Use of the isolated rat heart for the detection of cardiotoxic agents A. Cockburn
    5. Brain reaggregate cultures in neurotoxicological investigations C. K. Atterwill
    6. Application of thyroid cell culture to the study of thyrotoxicity C. G. Brown
    7. In vitro methods to investigate toxic lung disease A. Poole and R. C. Brown
    8. Metabolism and toxicity of drugs in mammalian hepatocyte culture R. J. Chenery
    9. In vitro evaluation of haemic systems in toxicology J. S. H. Luke and G. R. Betton
    Part II. General and Topical Toxicity:
    10. The chorioallantoic membrance in irritancy testing R. S. Lawrence
    11. In vitro dermal irritancy tests P. A. Duffy and O. P. Flint
    12. Genetic toxicology M. Richold
    13. In vitro immunotoxicology K. Miller, S. Nicklin and S. G. Volsen
    Part III. Reproductive Toxicity:
    14. An in vitro test for teratogens using cultures of rat embryo cells O. P. Flint
    15. Postimplantion embryo culture and its application to problems in teratology D. L. Cockroft and C. E. Steele
    16. Sub-mammalian and sub-vertebrate models in teratogenicity screening S. J. Freeman and N. A. Brown
    17. The use of in vitro techniques to investigate the action of testicular toxicants D. A. Garside
    18. An in vitro assessment of ovarian function: a potential tool for investigating mechanisms of toxicity in the ovary D. A. Garside and P. McKibbin
    Part IV. Conclusion:
    19. Conclusion C. K. Atterwill and C. E. Steele
    Index.

  • Editors

    C. K. Atterwill

    C. E. Steele

    Contributors

    G. B. Leslie, P. Johnson, M. A. Snith, W. R. Hewitt, J. Hook, E. S. Harpur, N. Sperelakis, G. Bkaily, A. Cockburn, C. K. Atterwill, C. G. Brown, A. Poole, R. C. Brown, R. J. Chenery, J. S. H. Luke, G. R. Betton, R. S. Lawrence, P. A. Duffy, O. P. Flint, M. Richold, K. Miller, S. Nicklin, S. G. Volsen, D. L. Cockroft, C. E. Steele, S. J. Freeman, N. A. Brown, D. A. Garside, P. McKibbin,

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