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Biochemical Oscillations and Cellular Rhythms
The Molecular Bases of Periodic and Chaotic Behaviour


  • Date Published: April 1997
  • availability: Available
  • format: Paperback
  • isbn: 9780521599467

£ 67.99

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About the Authors
  • This book addresses the molecular bases of some of the most important biochemical rhythms known at the cellular level. Clarifying the mechanism of these oscillatory phenomena is of key importance for understanding the origin as well as the physiological function of these rhythms, and the conditions in which simple periodic behaviour transforms into complex oscillations including bursting and chaos. It will appeal to graduate students and researchers in a wide variety of fields. On the one hand, it will be of interest to life scientists such as biochemists, cell biologists, medical scientists, pharmacologists and chronobiologists. On the other hand, scientists studying nonlinear phenomena, including oscillations and chaos, in chemistry, physics, mathematics and mathematical biology will also find these ideas of value.

    • Very well known author
    • Hot topic in nonlinear science/biochemistry
    • 1996 hardback edition received excellent reviews in a large number of scientific journals
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    Reviews & endorsements

    'The book beautifully illustrates the art of modelling … The author has been studying the theory of oscillations and rhythms for 25 years and brings a great deal of experience to bear on this book … It is an excellent read and will appeal to a wide-ranging audience, from students moving into the area to established researchers in the field, and from mathematical modellers to experimentalists in the life sciences.' Trends in Biochemical Sciences

    '… an extraordinarily impressive volume. I am fully confident that it will be the definitive work in this area for years to come.' Paul Rapp, Professor of Physiology, Medical College of Pennsylvania

    'It really is a very impressive tome and is a superb addition to the literature. It is quite clearly going to be the reference book on oscillations.' James D. Murray, Professor of Applied Mathematics and Mathematical Biology, University of Washington, Seattle

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    Product details

    • Date Published: April 1997
    • format: Paperback
    • isbn: 9780521599467
    • length: 632 pages
    • dimensions: 229 x 153 x 38 mm
    • weight: 0.9kg
    • contains: 5 b/w illus.
    • availability: Available
  • Table of Contents

    1. Introduction
    Part I. Glycolytic Oscillations:
    2. Oscillatory enzymes: simple periodic behaviour in an allosteric model for glycolytic oscillations
    Part II. From Simple to Complex Oscillatory Behaviour
    3. Birhythmicity: coexistence between two stable rhythms
    4. From simple periodic behaviour to complex oscillations, including bursting and chaos
    Part III. Oscillations Of Cyclic Amo In Dictyostelium Cells:
    5. Models for the periodic synthesis and relay of camp signals in Dictyostelium discoideum amoebae
    6. Complex oscillations and chaos in the camp signalling system of Dictyostelium
    7. The onset of camp oscillations in Dictyostelium as a model for the ontogenesis of biological rhythms
    Part IV. Pulsatile Signalling In Intercellular Communication:
    8. Function of the rhythm of intercellular communication in Dictyostelium. Link with pulsatile hormone secretion
    Part V. Calcium Oscillations:
    9. Oscillations and waves of intracellular calcium
    Part VI. The Mitotic Oscillator:
    10. Modelling the mitotic oscillator driving the cell division cycle
    Part VII. Circadian Rhythms:
    11. Towards a model for circadian oscillations in the Drosophila period protein (PER)
    12. Conclusions and perspectives

  • Author

    Albert Goldbeter, Université Libre de Bruxelles


    M. J. Berridge

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