Susceptibility to Infectious Diseases
The Importance of Host Genetics
- Editor: Richard Bellamy, Kintampo Health Research Centre, Ghana
In the last fifteen years, substantial progress has been made in identifying why some people are particularly susceptible to specific infectious diseases. Extensive evidence has accumulated that host genes are important determinants of the outcome of infection for many common pathogens. This book summarises advances that have been made in understanding the complexity of host genetic susceptibility. The diseases covered include those of great public health importance such as malaria and HIV, and those of topical interest such as Creutzfeldt-Jakob disease. Many different techniques have been used to identify host genes involved in infectious disease susceptibility. Each chapter describes how these discoveries were made and the book is therefore useful to anyone planning genetic studies on a multi-factorial disease, regardless of whether it has an infectious etiology.Read more
- The first to examine genetic susceptibility to infectious diseases, this book is written by leading international experts in the field
- Provides invaluable information on a wide range of strategies for identifying genetic factors involved in susceptibility to a multifactorial disease
Not yet reviewed
Be the first to review
Review was not posted due to profanity×
- Date Published: May 2006
- format: Adobe eBook Reader
- isbn: 9780511189067
- availability: This ISBN is for an eBook version which is distributed on our behalf by a third party.
Table of Contents
1. Introduction Richard Bellamy
2. Application of genetic epidemiology to dissecting host susceptibility/resistance to infection illustrated with the study of common mycobacterial infections Alexandre Alcais and Laurent Abel
3. The diverse genetic basis of immunodeficiencies Mauno Vihinen
4. Genetic diversity in the major histocompatibility complex and the immune response to infectious diseases Leland J. Yee and Mark R. Thursz
5. The cystic fibrosis transmembrane conductance regulator Alan W. Cuthbert
6. The influence of inherited traits on malaria infection David J. Roberts, Tyler Harris and Thomas Williams
7. Polymorphic chemokine receptor and ligand genes in HIV infection Jianming (James) Tang and Richard A. Kaslow
8. N-ramp and resistance in intracellular pathogens Philippe Gros and Erwin Schurr
9. The interleukin-12-interferon-γ loop is required for protective immunity to experimental and natural infections by mycobacterium Marion Bonnet, Claire Soudais and Jean-Laurent Casanova
10. Mannose-binding lectin deficiency and susceptibility to infectious disease Dominic L. Jack, Nigel J. Klein and Malcolm W. Turner
11. Blood group phenotypes and infectious diseases C. Caroline Blackwell, Donald M. Weir, Abdulhamid M. Alkout, Omar R. El Ahmer, Doris A. C. Mackenzie, Valerie S. James, J. Matthias Braun, Osama M. Almadani and Anthony Busuttil
12. Genetics of human susceptibility to infection and hepatic disease caused by schistosomes Alain J. Dessein, Nasureldin El Wali, Sandrine Marquet, Laurent Abel, Virmondes Rodrigues Jr., Carole Eboumbou Moukoko, Helia Dessein, Laurent Argiro, Sandrine Henri, Dominique Hillaire, Gachuhi Kimani, Aluizio Prata, Mubarak Magzoub and Christophe Chevillard
13. Genetic susceptibility to prion diseases Matthew Bishop and J. W. Ironside.
Find resources associated with this titleYour search for '' returned .
Type Name Unlocked * Format Size
This title is supported by one or more locked resources. Access to locked resources is granted exclusively by Cambridge University Press to lecturers whose faculty status has been verified. To gain access to locked resources, lecturers should sign in to or register for a Cambridge user account.
Please use locked resources responsibly and exercise your professional discretion when choosing how you share these materials with your students. Other lecturers may wish to use locked resources for assessment purposes and their usefulness is undermined when the source files (for example, solution manuals or test banks) are shared online or via social networks.
Supplementary resources are subject to copyright. Lecturers are permitted to view, print or download these resources for use in their teaching, but may not change them or use them for commercial gain.
If you are having problems accessing these resources please contact email@example.com.
Sorry, this resource is locked