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Introduction to the Blood-Brain Barrier
Methodology, Biology and Pathology

£79.00

William M. Pardridge, Eain M. Cornford, Tetsuya Terasaki, David J. Begley, Ulrich Bickel, Darryl R. Peterson, Richard A. Hawkins, Heinz Gögelein, Rüdiger Popp, Joachim Hoyer, Carsten T. Beuckmann, Hans-Joachim Galla, Kenneth L. Audus, Jayna M. Rose, Wen Wang, Ronald T. Borchardt, Elizabeth C. M. de Lange, Albertus G. de Boer, Douwe D. Breimer, Sukriti Nag, Joseph Fenstermacher, Ling Wei, Gitte M. Knudsen, Olaf B. Paulson, Sung-Cheng Huang, Carl Hoh, Jorge R. Barrio, Michael E. Phelps, Clive P. Hawkins, Ruben J. Boado, Lester R. Drewes, Hannelore Bauer, Quentin R. Smith, James Stoll, P. Borst, A. H. Schinkel, Richard F. Keep, Steven R. Ennis, A. Lorris Betz, Christian Frelin, Paul Vigne, Laurence Fenart, Bénédicte Dehouck, Marie-Pierre Dehouck, Roméo Cechelli, Mario Alberghina, Akira Tsuji, Ikumi Tamai, Malcolm Segal, Conrad E. Johanson, Lisa Prescott, Milton W. Brightman, N. R. Saunders, K. M. Dziegielewska, Lee L. Rubin, Louise Morgan, James M. Staddon, R. Béliveau, M. Demeule, E. Beaulieu, L. Jetté, Jean-Marie Bourre, Bürkhard Schlosshauer, Shoichiro Tsukita, Mikio Furuse, Masahiko Itoh, R. E. Catalán, Sylvie M. Cazaubon, Pierre Oliver Couraud, N. Joan Abbott, Roumen Balabanov, Paula Dore-Duffy, Maria. Spatz, Richard M. McCarron, Harry V. Vinters, Celia F. Brosnan, Luz Claudio, Mark Fisher, Henryk M. Wisniewski, Albert S. Lossinsky, Carol K. Petito, Barbro B. Johansson, P. A. Stewart, D. Mikulis, John T. Povlishock, Gareth Turner, Jaako Parkkinen
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  • Date Published: December 2006
  • availability: Available
  • format: Paperback
  • isbn: 9780521034272

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  • The blood-brain barrier serves to protect the brain from toxic substances whilst simultaneously allowing access to essential nutrients and chemical signals. At the interface between brain and body, knowledge of the blood-brain barrier forms an essential component in the complete understanding of a large proportion of medical disciplines. Nevertheless, it seems that ignorance of both the biology of this important membrane and the methodology suitable for its investigation still remains an impediment to progress in many fields, including, for example, the development of new and efficacious neuropharmaceuticals, cerebrovascular disease, Alzheimer's disease, cerebral AIDS and brain tumours. This introduction for both researchers and clinicians across the medical sciences is intended to aid both those beginning work directly in this area and those wishing simply to be better informed when interpreting information where the blood-brain barrier may be involved. Advances in both methodology and biology are detailed in 50 chapters from international authorities.

    • A really interesting introductory text
    • Written by international experts
    • Unique in its comprehensive coverage of biology, pathology and methodologies for blood-brain barrier research
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    Product details

    • Date Published: December 2006
    • format: Paperback
    • isbn: 9780521034272
    • length: 504 pages
    • dimensions: 246 x 188 x 27 mm
    • weight: 0.929kg
    • contains: 150 b/w illus. 29 tables
    • availability: Available
  • Table of Contents

    List of contributors
    1. Blood-brain barrier methodology and biology
    Part I. Methodology:
    2. The carotid artery single injection technique
    3. Development of the Brain Efflux Index (BEI) method and its application to the blood-brain barrier efflux transport study
    4. In situ brain perfusion
    5. Intravenous injection/pharmacokinetics
    6. Isolated brain capillaries: an in vitro model of blood-brain barrier research
    7. Isolation and behavior of plasma membrane vesicles made from cerebral capillary endothelial cells
    8. Patch clamp technique with isolated brain microvessel membranes
    9. Tissue culture of brain endothelial cells - induction of blood-brain barrier properties by brain factors
    10. Brain microvessel endothelial cell culture systems
    11. Intracerebral microdialysis
    12. Blood-brain barrier permeability measured with histochemistry
    13. Measuring local cerebral capillary permeability-surface area products by quantitative autoradiography
    14. Measurement of blood-brain barrier permeability in humans using indicator diffusion
    15. Measurement of blood-brain barrier permeability in humans with positron emission tomography
    16. Magnetic resonance imaging of blood-brain barrier permeability
    17. Molecular biology of brain capillaries
    Part II. Transport Biology:
    18. Biology of the blood-brain glucose transporter
    19. Glucose transporters in mammalian brain development
    20. Blood-brain barrier amino acid transport
    21. P-glycoprotein, a guardian of the brain
    22. Blood-brain barrier ion transport
    23. Ion channels in endothelial cells
    24. Interactions of lipoproteins with the blood-brain barrier
    25. Fatty acid and lipid intermediate transport
    26. Blood-brain barrier transport of drugs
    Part III. General Aspects of CNS Transport:
    27. The blood-CSF barrier and the choroid plexus
    28. Arachnoid membrane, subarachnoid CSF and pia-glia
    29. Circumventricular organs of the brain
    30. Transport in the developing brain
    Part IV. Signal Transduction/Biochemical Aspects:
    31. Regulation of brain endothelial cell tight junction permeability
    32. Chemotherapy and chemosensitization
    33. Lipid composition of brain microvessels
    34. Brain microvessel antigens
    35. Molecular dissection of tight junctions: occludin and ZO-1
    36. Phosphatidylinositol pathways
    37. Nitric oxide and endothelin at the blood-brain barrier
    38. Role of intracellular calcium in regulation of brain endothelial permeability
    39. Cytokines and the blood-brain barrier
    40. Blood-brain barrier and monoamines, revisited
    Part V. Pathophysiology in Disease States:
    41. Cerebral amyloid angiopathy
    42. Brain microvasculature in multiple sclerosis
    43. Hemostasis and the blood-brain barrier
    44. Microvascular pathology in cerebrovascular ischemia
    45. HIV infection and the blood-brain barrier
    46. Hypertension
    47. The blood-brain barrier in brain tumours
    48. The pathophysiology of blood-brain barrier dysfunction due to traumatic brain injury
    49. Cerebral malaria and the brain microvasculature
    50. Molecular basis of tissue tropism of bacterial meningitis.

  • Editor

    William M. Pardridge, University of California, Los Angeles, School of Medicine

    Contributors

    William M. Pardridge, Eain M. Cornford, Tetsuya Terasaki, David J. Begley, Ulrich Bickel, Darryl R. Peterson, Richard A. Hawkins, Heinz Gögelein, Rüdiger Popp, Joachim Hoyer, Carsten T. Beuckmann, Hans-Joachim Galla, Kenneth L. Audus, Jayna M. Rose, Wen Wang, Ronald T. Borchardt, Elizabeth C. M. de Lange, Albertus G. de Boer, Douwe D. Breimer, Sukriti Nag, Joseph Fenstermacher, Ling Wei, Gitte M. Knudsen, Olaf B. Paulson, Sung-Cheng Huang, Carl Hoh, Jorge R. Barrio, Michael E. Phelps, Clive P. Hawkins, Ruben J. Boado, Lester R. Drewes, Hannelore Bauer, Quentin R. Smith, James Stoll, P. Borst, A. H. Schinkel, Richard F. Keep, Steven R. Ennis, A. Lorris Betz, Christian Frelin, Paul Vigne, Laurence Fenart, Bénédicte Dehouck, Marie-Pierre Dehouck, Roméo Cechelli, Mario Alberghina, Akira Tsuji, Ikumi Tamai, Malcolm Segal, Conrad E. Johanson, Lisa Prescott, Milton W. Brightman, N. R. Saunders, K. M. Dziegielewska, Lee L. Rubin, Louise Morgan, James M. Staddon, R. Béliveau, M. Demeule, E. Beaulieu, L. Jetté, Jean-Marie Bourre, Bürkhard Schlosshauer, Shoichiro Tsukita, Mikio Furuse, Masahiko Itoh, R. E. Catalán, Sylvie M. Cazaubon, Pierre Oliver Couraud, N. Joan Abbott, Roumen Balabanov, Paula Dore-Duffy, Maria. Spatz, Richard M. McCarron, Harry V. Vinters, Celia F. Brosnan, Luz Claudio, Mark Fisher, Henryk M. Wisniewski, Albert S. Lossinsky, Carol K. Petito, Barbro B. Johansson, P. A. Stewart, D. Mikulis, John T. Povlishock, Gareth Turner, Jaako Parkkinen

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