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The Neurobiology of Disease

The Neurobiology of Disease
Contributions from Neuroscience to Clinical Neurology

£142.00

J. M. Ritchie, S. G. Waxman, M. Baker, T. Konishi, G. Reid, P. Grafe, J. Newsom-Davis, M. P. Pender, T. E. Feasby, K. J. Smith, W. I. McDonald, J. Rosenbluth, J. Ochoa, A. Iggo, R. H. Westgaard, W. D. Willis Jnr, E. Shen, W. E. Crill, J. G. R. Jefferys, P. Anderson, E. Moser, V. Jensen, A. Taylor, R. Durbarba, M. Aminoff, S. Goodin, A. Prochazka, M. Gorassini, J. Taylor, N. Nishimaru, W. Burke, H.-J. Freund, A. J. Berger, D. A. Bayliss, F. Viana, G. Hilaire, D. Morin, E. Di Pasquale, R. Monteau, L. Grélot, S. Milano, C. Gestreau, A. Bianchi, J. R. Romaniuk, T. E. Dick, G. S. Supinski, A. F. DiMarco, M. Goldman, B. Duron, C. P. Seers, R. S. Howard, G. H. Mills, M. Green, J. Diamond, A. Gloster, I. P. Johnson, J. B. Munson, H. Nishimura, J. G. Nicholls, Z. Varga, A. H. Pullen, C. Krieger
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  • Date Published: April 1996
  • availability: Available
  • format: Hardback
  • isbn: 9780521451321

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About the Authors
  • This volume demonstrates the value of interactions between neurology and the basic sciences that underpin it. The text considers a range of topics from the points of view of both neurobiologist and clinician and reveals how advances in our understanding are made. The selected topics cover a wide range of levels of organization in the nervous system. For each one, distinguished researchers from around the world make contributions, including general reviews of normal and pathological mechanisms as well as detailed accounts of the basic processes involved. The book's coverage boasts an excellent section on the physiology and pathophysiology of central and peripheral nerve fibres. Also of particular note are the chapters on neuronal plasticity, cell death and axonal regeneration. The book is dedicated to Tom Sears, who at the time of its original publication was retiring as Professor at London's Institute of Neurology (Queen Square).

    • Contributors were leading researchers in their fields
    • Unique combination of clinicians and scientists
    • Special coverage of nerve function and dysfunction
    • Unique coverage of neurological aspects of respiratory control
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    Product details

    • Date Published: April 1996
    • format: Hardback
    • isbn: 9780521451321
    • length: 464 pages
    • dimensions: 235 x 156 x 28 mm
    • weight: 0.85kg
    • availability: Available
  • Table of Contents

    Part I. Physiology and Pathophysiology of Nerve Fibres:
    1. Ion channels in normal and pathophysiological mammalian peripheral myelinated nerve J. M. Ritchie
    2. Molecular anatomy of the node of Ranvier: newer concepts S. G. Waxman
    3. Delayed rectifier type K+ currents in rabbit and rat axoms and Schwann cells M. Baker
    4. Axonal signals for potassium channel expression in Schwann cells T. Konishi
    5. Ion channels in human axons G. Reid
    6. An in vitro model of diabetic neuropathy: electrophysiological studies P. Grafe
    7. Autoimmunity at the neuromuscular junction J. Newsom-Davis
    8. The immunopathology and pathophysiology of experimental autoimmune encephalomyelitis M. P. Pender
    9. The pathophysiology of human demyelinating neuropathies T. E. Feasby
    10. Conduction properties of central demyelinated axons: the generation of symptoms in demyelinating disease K. J. Smith
    11. The mechanisms of relapse and remission in multiple sclerosis W. I. McDonald
    12. Glial transplantation in the treatment of myelin loss or deficiency J. Rosenbluth
    Part II. Pain:
    13. Human nociceptors in health and disease J. Ochoa
    14. The sensory consequences of inflammation A. Iggo
    15. Non-voluntary motor unit activity and myofascial pain syndromes R. H. Westgaard
    16. Is there a mechanism for the spinal cord to remember pain? W. D. Willis Jnr
    17. The neurophysiological basis of pain relief by acupuncture E. Shen
    Part III. Control of Central Nervous System Output:
    18. Synaptic transduction in neocortical neurones W. E. Crill
    19. Cortical circuits, synchronization and seizures J. G. R. Jefferys
    20. Physiologically induced changes of brain temperature and their effect on extracellular field potentials P. Anderson, E. Moser, and V. Jensen
    21. Fusimotor patterns of respiratory muscles A. Taylor, and R. Durbarba
    22. Cerebral accompaniments and functional significance of the long-latency stretch reflexes in human forearm muscles M. Aminoff, and S. Goodin
    23. The cerebellum and proprioceptive control of movement A. Prochazka et al
    24. Roles of the lateral nodulus and uvula of the cerebellum in cardiovascular control N. Nishimaru
    25. Central actions of curare and gallamine: implications for reticular reflex myoclonus W. Burke
    26. The pathophysiology of upper motoneurone disorders H-J. Freund
    27. Modulation of hypoglossal motoneurones by thyrotropin releasing hormone and serotonin A. J. Berger et al
    28. Serotonin and central respiratory disorders in the newborn G. Hilaire, D. Morin et al
    29. Are medullary respiratory neurones multipurpose neurones? L. Grélot et al
    30. Reflex control of expiratory motor output in dogs J. R. Romaniuk et al.
    31. Abnormal thoracoabdominal movements in patients with chronic lung disease M. Goldman
    32. Respiratory rhythm and apnoeas in the newborn B. Duron
    33. Cardiorespiratory interactions during apnoea C. P. Seers
    34. Impairment of respiratory control in neurological disease R. S. Howard
    35. The respiratory muscles in neurological disease G. H. Mills and M. Green
    Part IV. Development, Survival, Regeneration and Death:
    36. Axonal growth and plasticity in the adult nervous system J. Diamond, and A. Gloster
    37. Target dependence of motoneurones I. P. Johnson
    38. Rescue of neurones cross-regenerated into foreign targets J. B. Munson, and H. Nishimura
    39. Development and repair of neonatal mammalian spinal cord in culture J. G. Nicholls, and Z. Varga
    40. Selective neuronal vulnerability in motor neurone diseases with reference to sparing of Onuf's nucleus A. H. Pullen
    41. Excitotoxicity in motor neurone diseases C. Krieger.

  • Editors

    Hugh Bostock, Institute of Neurology, London

    P. A. Kirkwood, Institute of Neurology, London

    A. H. Pullen, Institute of Neurology, London

    Contributors

    J. M. Ritchie, S. G. Waxman, M. Baker, T. Konishi, G. Reid, P. Grafe, J. Newsom-Davis, M. P. Pender, T. E. Feasby, K. J. Smith, W. I. McDonald, J. Rosenbluth, J. Ochoa, A. Iggo, R. H. Westgaard, W. D. Willis Jnr, E. Shen, W. E. Crill, J. G. R. Jefferys, P. Anderson, E. Moser, V. Jensen, A. Taylor, R. Durbarba, M. Aminoff, S. Goodin, A. Prochazka, M. Gorassini, J. Taylor, N. Nishimaru, W. Burke, H.-J. Freund, A. J. Berger, D. A. Bayliss, F. Viana, G. Hilaire, D. Morin, E. Di Pasquale, R. Monteau, L. Grélot, S. Milano, C. Gestreau, A. Bianchi, J. R. Romaniuk, T. E. Dick, G. S. Supinski, A. F. DiMarco, M. Goldman, B. Duron, C. P. Seers, R. S. Howard, G. H. Mills, M. Green, J. Diamond, A. Gloster, I. P. Johnson, J. B. Munson, H. Nishimura, J. G. Nicholls, Z. Varga, A. H. Pullen, C. Krieger

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