Skip to content
Register Sign in Wishlist
Look Inside Cyclopenta[a]phenanthrenes



Part of Cambridge Monographs on Cancer Research

  • Date Published: December 2008
  • availability: Available
  • format: Paperback
  • isbn: 9780521101929

£ 35.99

Add to cart Add to wishlist

Looking for an inspection copy?

This title is not currently available on inspection

Product filter button
About the Authors
  • This volume looks in detail at the chemistry and carcinogenicity of the cyclopenta[a]phenanthrenes; these are fully aromatic (i.e. dehydrogenated) derivatives of physiologically important hormones, the steroids and some have been shown to be powerful carcinogens in animal models. Others have been found to be of widespread occurrence in the environment where they are probably derived from plant steroids. This book covers all aspects of this class of compounds including their chemical syntheses and chemistry, occurrence, physical and spectral properties, metabolism, carcinogenicity and mutagenicity. It also outlines how steroid biochemistry indicates the way in which these molecules might be formed in vivo as a result of incorrect steroid metabolism and ends with a call for the application of powerful modern analytical techniques to the problem of whether they do occur in this way and are a cause of human cancer.

    Customer reviews

    Not yet reviewed

    Be the first to review

    Review was not posted due to profanity


    , create a review

    (If you're not , sign out)

    Please enter the right captcha value
    Please enter a star rating.
    Your review must be a minimum of 12 words.

    How do you rate this item?


    Product details

    • Date Published: December 2008
    • format: Paperback
    • isbn: 9780521101929
    • length: 288 pages
    • dimensions: 229 x 152 x 16 mm
    • weight: 0.43kg
    • availability: Available
  • Table of Contents

    Author's preface
    1. Introduction
    2. Chemical synthesis of cyclopenta[a]phenanthrenes: hydrocarbons
    3. Chemical synthesis of cyclopent[a]phenanthenes: ring-D ketones
    4. General chemistry of cyclopenta[a]phenanthrenes
    5. Physical and spectral properties of cyclopenta[a]phenanthrenes
    6. Carcinogenicity and mutagenicity of cyclopenta[a]phenanthrenes
    7. Metabolic activation of cyclopenta[a]phenanthrenes and their interaction with DNA
    8. X-ray crystallography of some cyclopenta[a]phenanthrenes: an apparent correlation between molecular strain and carcinogenicity
    9. Conclusion
    General Index.

  • Authors

    Maurice M. Coombs

    Tarlochan S. Bhatt

Sign In

Please sign in to access your account


Not already registered? Create an account now. ×

Sorry, this resource is locked

Please register or sign in to request access. If you are having problems accessing these resources please email

Register Sign in
Please note that this file is password protected. You will be asked to input your password on the next screen.

» Proceed

You are now leaving the Cambridge University Press website. Your eBook purchase and download will be completed by our partner Please see the permission section of the catalogue page for details of the print & copy limits on our eBooks.

Continue ×

Continue ×

Continue ×

Find content that relates to you

Join us online

This site uses cookies to improve your experience. Read more Close

Are you sure you want to delete your account?

This cannot be undone.


Thank you for your feedback which will help us improve our service.

If you requested a response, we will make sure to get back to you shortly.

Please fill in the required fields in your feedback submission.