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Familial Breast and Ovarian Cancer
Genetics, Screening and Management

£68.00

Patrick Morrison, Shirley Hodgson, Neva Haites, Helen Gregory, Charis Eng, Pierre Chappuis, Will Foulkes, Hans Vasen, M. A. Nooy, Dominique Stoppa-Lyonnet, Will Foulkes, Pierre Chappuis, Sunil Lakhani, Adrienne M. Flanagan, Jenny Chang-Claude, Heiko Becher, Jonathon Gray, Diana Eccles, Pål Møller, Michael Steel, Barnaby Rufford, Usha Menon, Ian Jacobs, Pierre Chappuis, Will Foulkes, Dirk Brinkman, Ian Jacobs, Gareth Evans, Fiona Lalloo, Andrew Balidam, Steven Sutton, Alison Bish, Lucy Brooks, Richard Kennedy, Patrick Johnston
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  • Date Published: July 2005
  • availability: Available
  • format: Paperback
  • isbn: 9780521017770

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About the Authors
  • This publication surveys the profound and far-reaching ramifications that have arisen from the very significant advances in our understanding of the genetic basis of familial breast and ovarian cancer. Written by international experts from Europe and North America, this book provides the busy clinician with a contemporary and wide-ranging guide to the latest developments in the diagnosis, genetics, screening, prevention and management of familial breast cancer. This area has advanced in knowledge so rapidly that this publication provides an unrivalled source of information including sections on ethical and insurance issues and the different cultural differences in breast cancer. The use of recently devised cancer genetics clinics and different referral criteria and patterns to these clinics are detailed. The volume will be of immense value to all clinical geneticists, oncologists, and healthcare professionals involved in screening and counselling programmes.

    • Covers molecular biology and natural history, screening, and management
    • Includes advice on healthcare provision and setting up cancer genetics services
    • Includes the latest developments and their impact on the study and treatment of familial breast and ovarian cancer
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    Reviews & endorsements

    '… this is a very good state of the art document of the current knowledge, covering most aspects of the genetic background and the clinical management of suspected familial breast and ovarian cancer in mid-2002 … for those in the phase of starting up a clinical service the book contains valuable information and would be very useful as a basic guide…'. Human Genetics

    'Colleagues throughout the profession from a wide range of disciplines will find much in this book to interest them and will help them guide and manage their patients through the difficult decision journey of familial cancer.' The Ulster Medical Journal

    ' … members of the cancer genetics team who found it immediately useful … the usefulness of the text is such that I found myself reading it from cover to cover. No chapter is weak … I recommend it to all clinical geneticists working in cancer genetics, to breast surgeons and gynaecologists who deal with these cancers, and to radiologists involved in screening programmes. It provides an excellent review of the state of the art, with all the relevant references. Journal of the Royal Society of Medicine

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    Product details

    • Date Published: July 2005
    • format: Paperback
    • isbn: 9780521017770
    • length: 420 pages
    • dimensions: 254 x 179 x 26 mm
    • weight: 1.076kg
    • contains: 52 tables
    • availability: Available
  • Table of Contents

    Part I. Molecular Biology and Natural History:
    1. Introduction Patrick Morrison, Shirley Hodgson and Neva Haites
    2. Overview of clinical genetics of breast cancer Neva Haites and Helen Gregory
    3. Cowden syndrome and related disorders Charis Eng
    4. Overview of clinical genetics of ovarian cancer Pierre Chappuis and Will Foulkes
    5. Ovarian cancer as part of HNPCC and other hereditary colon cancer syndromes Hans Vasen and M. A. Nooy
    6. Natural history of hereditary breast cancer Dominique Stoppa-Lyonnet, Will Foulkes and Pierre Chappuis
    7. Pathology of the breast and ovary in mutation carriers Sunil Lakhani and Adrienne M. Flanagan
    8. Risk estimation for familial breast and ovarian cancer Jenny Chang-Claude and Heiko Becher
    Part II. Screening:
    9. Experience of setting up a cancer genetics service Jonathon Gray
    10. Referral criteria for cancer genetics clinics Diana Eccles
    11. Service aspects of cancer genetic clinics Neva Haites and Shirley Hodgson
    12. Cultural and education aspects influencing development of cancer genetics services in different European countries Shirley Hodgson
    13. Screening, detection and survival patterns of breast and other cancers in high risk families Pål Møller and Michael Steel
    14. Screening for familial ovarian cancer Barnaby Rufford, Usha Menon and Ian Jacobs
    Part III. Management:
    15. Management of BRCA 1/2 mutation carriers Pierre Chappuis and Will Foulkes
    16. Management of ovarian cancer Dirk Brinkman and Ian Jacobs
    17. Prophylactic mastectomy in mutation carriers Gareth Evans, Fiona Lalloo and Andrew Balidam
    18. Psychosocial aspects of genetic counselling Steven Sutton and Alison Bish
    19. BRCA 1 and 2 testing: uptake and its measurement Lucy Brooks and Gareth Evans
    20. Ethical aspects Patrick Morrison and Michael Steel
    21. Gene therapy of breast and ovarian cancer Richard Kennedy and Patrick Johnston
    22. Future directions Patrick Morrison, Shirley Hodgson and Neva Haites.

  • Editors

    Patrick J. Morrison, Belfast City Hospital, Belfast
    Patrick J. Morrison is a consultant clinical geneticist with a special interest in cancer genetics, in the Northern Ireland Regional Genetics Service. He qualified with an MB BCh BAO in 1986 and an MD in 1993 from Queens' University Belfast. He held molecular biology and neurogenetics research fellowships from the Royal College of Physicians in Ireland from 1991–4. Morrison is a member of the UK Government's Human Genetics Commission, World Federation of Neurology Research Group in Huntingdon Disease, a steering group member on the International Collaborative group on hereditary breast and ovarian cancer (ICG-HBOC) and a council member of the Irish Society of Human Genetics. He is involved in many other genetics and cancer societies, and has published over 100 peer-reviewed articles on all aspects of genetics, particularly late onset neurogenetics diseases, familial cancers and insurance issues.

    Shirley V. Hodgson, Guy's Hospital, London

    Neva E. Haites, University of Aberdeen
    Neva E. Haites is a Professor in Medical Genetics at the University of Aberdeen and Head of Service in Medical Genetics and Honorary Consultant Clinical Genetics, Grampian University Hospitals NHS Trust. Her clinical interests include families with an inherited predisposition to cancer. She is currently Chair the Cancer Genetics Sub-Group of the Scottish Cancer Group at the Scottish Office and Chair of the British Society of Human Genetics. Haites' research Interests include service models for familial cancer, molecular aspects of Charcot Marie Tooth disease, polycystic ovarian syndrome, talipes equino varus, and diagnosis and identification of genes implicated in sporadic and familial cancer.

    Contributors

    Patrick Morrison, Shirley Hodgson, Neva Haites, Helen Gregory, Charis Eng, Pierre Chappuis, Will Foulkes, Hans Vasen, M. A. Nooy, Dominique Stoppa-Lyonnet, Will Foulkes, Pierre Chappuis, Sunil Lakhani, Adrienne M. Flanagan, Jenny Chang-Claude, Heiko Becher, Jonathon Gray, Diana Eccles, Pål Møller, Michael Steel, Barnaby Rufford, Usha Menon, Ian Jacobs, Pierre Chappuis, Will Foulkes, Dirk Brinkman, Ian Jacobs, Gareth Evans, Fiona Lalloo, Andrew Balidam, Steven Sutton, Alison Bish, Lucy Brooks, Richard Kennedy, Patrick Johnston

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