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Look Inside Genetic Variation and Human Disease

Genetic Variation and Human Disease
Principles and Evolutionary Approaches


Part of Cambridge Studies in Biological and Evolutionary Anthropology

  • Date Published: February 1995
  • availability: Available
  • format: Paperback
  • isbn: 9780521336604

£ 35.99

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About the Authors
  • Recent developments in molecular and computational methods have made it possible to identify the genetic basis of any biological trait, and have led to spectacular advances in the study of human disease. This book provides an overview of the concepts and methods needed to understand the genetic basis of biological traits, including disease, in humans. Using examples of qualitative and quantitative phenotypes, Professor Weiss shows how genetic variation may be quantified, and how relationships between genotype and phenotype may be inferred. This book will appeal to many biologists and biological anthropologists interested in the genetic basis of biological traits, as well as to epidemiologists, biomedical scientists, human geneticists and molecular biologists.

    • Topical subject (human genome project is very high profile)
    • Good reviews for hardback edition
    • No other up-to-date book covers this range of topics
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    Reviews & endorsements

    'A well-documented, clearly written, scholarly text.' S. Antonarakis, Trends in Genetics

    'By far the best introduction to the subject that I have read.' D. Weatherall, Science Publicity

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    Product details

    • Date Published: February 1995
    • format: Paperback
    • isbn: 9780521336604
    • length: 380 pages
    • dimensions: 229 x 152 x 21 mm
    • weight: 0.56kg
    • contains: 71 b/w illus. 42 tables
    • availability: Available
  • Table of Contents

    Part I. Genes and Their Expression:
    1. What is a gene?
    2. The logic of the genome
    3. Concepts of frequency and association in populations
    4. Genes and phenotypes in populations
    Part II. Introduction to Genetic Epidemiology: Inference from Observational Data:
    5. Segregation analysis: discrete traits in families
    6. Segregation analysis: quantitative traits in families
    7. Linkage analysis: finding and mapping genes for qualitative traits
    8. Linkage analysis: finding and mapping genes for quantitative traits
    Part III. Evolution: The Time Dimension in Populations:
    9. Genes over time and space
    10. Reconstructing history: the footprints of evolution
    11. Evolution generates heterogeneity
    Part IV. Modification of the Inherited Genotype: The Time Dimension in Individuals:
    12. Phenotype amplification by the environment
    13. Infectious disease: the response to biological challenge
    14. Variation within the inherited genotype
    15. Cancer and ageing: a microcosm of evolution during life
    Afterwords: towards a unified general model

  • Author

    Kenneth M. Weiss, Pennsylvania State University

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