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Cell Therapy

Cell Therapy
Stem Cell Transplantation, Gene Therapy, and Cellular Immunotherapy

£194.00

Part of Cancer: Clinical Science in Practice

Malcolm Moore, Shimon Slavin, Judy Gasson, Michael Lill, C. Glenn Begley, Dieter Rectenwald, Ned Waller, David Bodine, Elizabeth J. Shpall, Usala Gehling, Pablo Cagnori, Scott Bearman, Christopher Hogan, Roy B. Jones, Luen BikTo, David Haylock, Peg Dyson, Paul Simmons, Chris Juttner, William P. Sheridan, Ann Tsukomoto, Dennis Sasaki, Benjamin Chin, Ronald Hoffman, Karen Auditore-Hargreaves, Monica Krierger, Shelly Heimfeld, Ronal Berenson, Stefan Miltenyi, David Haylock, William Kidwell, John Gribben, Lee M. Nadler, Russell Basser, Richard Fox, David Feenley, George Raptis, John P. A. Crown, Larry Norton, Lother Kanz, Marion Subkiewe, Wolfram Brugger, James O. Armitage, Philip Bierman, Michael Bishop, Fredrick R. Appelbaum, Cynthia Dunbar, Jeffrey Medin, Makoto Migita, Stefan Karlsson, Randal Byrn, Vera Malkovska, Paul Sondel, William E. Carson, Michael Caligiuri, Lori Minasian, Susan Osanto, Peter Schrier, Kristin Maakestad, Rosemary Mazaney, W. Conrad Liles, David C. Dale, Arnon Nagler, Shoshana Morecki, Aliza Ackerstein, Reuven Or, Elizabeth Naparstek, Frits van Rhee, John Goldman, David Porter, Joseph H. Antin
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  • Date Published: June 1996
  • availability: Available
  • format: Hardback
  • isbn: 9780521473156

£ 194.00
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  • Cell therapy is a rapidly developing area, drawing on cell biology, molecular biology, virology, immunology, cell quantitation techniques and biomedical engineering. It has potential in many clinical settings, in the treatment of cancer and other diseases. This volume in the series Cancer: Clinical Science in Practice examines the current state and future prospects of cell therapy, which seems likely to have an even more profound impact on health care than did the production of proteins by recombinant DNA technology. The coverage is broad, including the scientific principles of haematopoietic cell therapy, the technology of cell collection and preparation, current and likely future clinical applications of cell therapy, and the principles and practice of cellular immunotherapy. Up-to-date and authoritative, volumes in this series are intended for a wide audience of clinicians and researchers with an interest in the applications of biomedical science to the understanding and management of cancer.

    • Fastest growing area in cancer treatment
    • Brings together expertise from academic departments and biotechnology industry
    • Ranges from basic cell biology to clinical and regulatory issues
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    Reviews & endorsements

    ' … a well-written and very informative book which provides an excellent overview over the rapidly expanding field of hematopoietic cell therapy.' Friedrich Schuening, Oncology

    'This timely book largely succeeds in its goal of providing a snapshot of this rapidly expanding field.' Stephen Devereux, Journal of Medical Genetics

    '… an excellent and timely text … strongly recommended …'. N. H. Russell, The Lancet

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    Product details

    • Date Published: June 1996
    • format: Hardback
    • isbn: 9780521473156
    • length: 647 pages
    • dimensions: 235 x 157 x 35 mm
    • weight: 1.02kg
    • contains: 71 b/w illus. 5 colour illus. 34 tables
    • availability: Available
  • Table of Contents

    Part I. Aspects of Hematopoiesis:
    1. Overview of hematopoiesis and review of cells needed for hematopoietic reconstitution
    2. Review of cells important for adoptive cellular immunotherapy
    3. Potential uses of defined cell populations
    4. Progenitor cell assays
    5. Flow cytometric techniques
    6. Principles of gene therapy
    7. Sources of progenitor cells
    8. Chemotherapy approaches to mobilization of progenitor cells
    9. Cytokine approaches to mobilization of progenitor cells
    10. Stem cell isolation
    11. Methods of cell selection using monoclonal antibodies
    12. Magnetic approaches to cell separation
    13. Growth factors and ex-vivo expansion of hematopoietic progenitor cells
    14. Bioreactors for expansion
    15. Purging of malignant cells
    Part II. Current Clinical Approaches:
    16. What can be achieved without cell therapy
    17. Clinical potential of hematopoietic growth-factor support for high-dose chemotherapy
    18. Review of high-dose chemotherapy requiring cellular support in solid tumors
    19. Review of high-dose chemotherapy requiring cellular support in hematological malignancies
    20. Review of the potential use of cell therapy in leukemia
    Part III. Future Clinical Applications:
    21. Clinical gene therapy
    22. Correction of inborn errors
    23. Cellular therapy approaches to the treatment of AIDS
    Part IV. Experimental and Clinical Cellular Immunotherapy:
    24. Adoptive immunotherapy with T cells
    25. Cellular adoptive immunotherapy with natural killer cells
    26. Autologous tumor cell vaccines
    27. Allogeneic cellular vaccines against tumors
    28. Neutrophil transfusions for treatment of infections
    29. Experimental and clinical cellular immunotherapy in bone-marrow transplantation
    30. Donor lymphocyte therapy in bone-marrow transplantation
    31. Graft-versus-leukemia effect in bone-marrow transplantation.

  • Editors

    George Morstyn

    William Sheridan, Amgen Inc.

    Contributors

    Malcolm Moore, Shimon Slavin, Judy Gasson, Michael Lill, C. Glenn Begley, Dieter Rectenwald, Ned Waller, David Bodine, Elizabeth J. Shpall, Usala Gehling, Pablo Cagnori, Scott Bearman, Christopher Hogan, Roy B. Jones, Luen BikTo, David Haylock, Peg Dyson, Paul Simmons, Chris Juttner, William P. Sheridan, Ann Tsukomoto, Dennis Sasaki, Benjamin Chin, Ronald Hoffman, Karen Auditore-Hargreaves, Monica Krierger, Shelly Heimfeld, Ronal Berenson, Stefan Miltenyi, David Haylock, William Kidwell, John Gribben, Lee M. Nadler, Russell Basser, Richard Fox, David Feenley, George Raptis, John P. A. Crown, Larry Norton, Lother Kanz, Marion Subkiewe, Wolfram Brugger, James O. Armitage, Philip Bierman, Michael Bishop, Fredrick R. Appelbaum, Cynthia Dunbar, Jeffrey Medin, Makoto Migita, Stefan Karlsson, Randal Byrn, Vera Malkovska, Paul Sondel, William E. Carson, Michael Caligiuri, Lori Minasian, Susan Osanto, Peter Schrier, Kristin Maakestad, Rosemary Mazaney, W. Conrad Liles, David C. Dale, Arnon Nagler, Shoshana Morecki, Aliza Ackerstein, Reuven Or, Elizabeth Naparstek, Frits van Rhee, John Goldman, David Porter, Joseph H. Antin

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