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Look Inside The Clozapine Handbook

The Clozapine Handbook
Stahl's Handbooks

£39.99

Part of Stahl's Essential Psychopharmacology Handbooks

  • Publication planned for: July 2019
  • availability: Not yet published - available from July 2019
  • format: Paperback
  • isbn: 9781108447461

£ 39.99
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About the Authors
  • Real-world and clinical trial data support that clozapine is the only effective antipsychotic for treatment resistant schizophrenia and other severe mental illnesses. Clozapine also reduces rates of suicidality, psychiatric hospitalization and all-cause mortality. However, clozapine is underutilized for two reasons: misunderstandings of its efficacy benefits and misapprehension of, limited knowledge or misinformation about the management of treatment related risks and adverse effects. In response to worldwide efforts to promote clozapine use, this user-friendly handbook provides clinicians with evidence-based approaches for patient management as well as logical approaches to the management of clinical situations and adverse effects. It outlines clearly the rationale for specific management decisions and prioritises the options based on this logic. This Handbook is designed for use by clinicians worldwide and is essential reading for all mental health care professionals.

    • The increased interest in promoting greater clozapine use internationally means this book fills a gap in the market for clinicians who seek evidence-based advice on best practices
    • Use of clozapine has shown real world benefits such as a reduction in suicidality, psychiatric hospitalization and mortality rates. Many clinicians are unfamiliar with recent improvements in the understanding of clozapine-related dosing and adverse effect management
    • Provides a logical, evidence-based framework for important clinical issues - this handbook leads the clinician through the reasoning process for adverse effect management and other common clinical situations
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    Product details

    • Publication planned for: July 2019
    • format: Paperback
    • isbn: 9781108447461
    • dimensions: 208 x 213 x 13 mm
    • weight: 0.32kg
    • contains: 24 b/w illus.
    • availability: Not yet published - available from July 2019
  • Table of Contents

    Preface
    1. Initiating Clozapine
    2. Understanding hematologic monitoring and benign ethnic neutropenia
    3. Binding profile, metabolism, kinetics, drug interactions and use of plasma levels
    4. Managing constipation
    5. Managing sialorrhea
    6. Managing sedation, orthostasis and tachycardia
    7. Managing metabolic adverse effects
    8. Managing seizure risk and stuttering
    9. Fever, myocarditis, interstitial nephritis, DRESS, serositis and cardiomyopathy
    10. Eosinophilia, leukocytosis, thrombocytopenia, thrombocytosis, anemia, hepatic function abnormalities
    11. Managing enuresis and incontinence, priapism, venous thromboembolism, neuroleptic malignant syndrome, tardive dyskinesia and obsessive compulsive disorder
    12. The efficacy story: treatment resistant schizophrenia, psychogenic polydipsia, treatment intolerant schizophrenia, suicidality, violence, mania and Parkinson's disease psychosis
    13. Addressing clozapine positive symptom nonresponse in schizophrenia spectrum patients
    14. Discontinuing clozapine and management of cholinergic rebound
    15. Special topics: child and adolescent patients, elderly patients, patients with intellectual disability, pregnancy and risk for major congenital malformation, lactation, overdose, postmortem redistribution
    Index.

  • Authors

    Jonathan M. Meyer, University of California, San Diego
    Jonathan M. Meyer is currently a Clinical Professor of Psychiatry at the University of California, San Diego and a Psychopharmacology Consultant to the California Department of State Hospitals. Dr Meyer is an internationally recognised speaker on psychopharmacology and the treatment of severe mental illness, and is Distinguished Fellow of the American Psychiatric Association.

    Stephen M. Stahl, University of California, San Diego
    Stephen M. Stahl is currently a Professor at the University of California, San Diego and serves as Honorary Fellow in the psychiatry department at the University of Cambridge. He is also the Chairman of the Neuroscience Education Institute (NEI) and Arbor Scientia Group. Dr Stahl serves as the Director of Psychopharmacology Services at the California Department of State Hospitals as well as the Editor-in Chief of CNS Spectrums.

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