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Immunological Aspects of the Vascular Endothelium

£36.99

Part of Cambridge Reviews in Clinical Immunology

Daniel M. Altmann, Jeremy D. Pearson, Michael J. May, Sussan Nourshargh, Ann Ager, Virginia Calder, John Greenwood, H. L. C. Beynon, P. Athanassiou, K. A. Davies, R. J. Moots, P. Emery, Abeed A. Pall, Caroline O. S. Savage, M. J. Dillon, Carla Zoja, Guiseppe Remuzzi, John R. Bradley
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  • Date Published: February 2011
  • availability: Available
  • format: Paperback
  • isbn: 9780521184311

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About the Authors
  • Originally published in 1995, this volume looks at the functioning of the vascular endothelium, and the diseases and tissue injury that arise as a result of inflammation and immunological responses. The vascular endothelium is a metabolically highly active layer of cells lining all blood vessel walls. Through its interactions with leucocytes and other mediators, it is central to the development of inflammatory foci and to lymphocyte trafficking around the body. Tissue injury may arise here as a result of abnormal inflammatory or immune responses. The potential for such injury to contribute to autoimmune disease is discussed in this book, particularly in relation to autoimmune vascular disease of the renal, rheumatological and neurological systems, as well as in organ transplantation.

    • Spans basic science and medical diseases
    • Includes review of concepts of inflammation and immunity
    • Of importance to transplantation medicine
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    Product details

    • Date Published: February 2011
    • format: Paperback
    • isbn: 9780521184311
    • length: 274 pages
    • dimensions: 229 x 152 x 16 mm
    • weight: 0.41kg
    • availability: Available
  • Table of Contents

    1. New concepts of mechanisms in autoimmunity
    2. Regulation of endothelial cell function by cytokines
    3. Interactions between granulocytes and endothelium
    4. The regulation of lymphocyte migration by vascular endothelium and its role in the immune response
    5. The role of the vascular endothelium in immunologically-mediated neurological diseases
    6. The role of the endothelium in systemic lupus erythematosus and Sjögren's syndrome
    7. The role of the endothelium in rheumatoid arthritis and scleroderma
    8. The role of the endothelium in systemic vasculitis
    9. Endothelial involvement in childhood Kawasaki disease
    10. The role of the endothelium in thrombotic thrombocytopaenic purpura and haemolytic uraemic sydrome
    11. The immunological role of the endothelium in organ transplantation
    Index.

  • Editors

    Caroline O. S. Savage, University of Birmingham

    Jeremy D. Pearson, King's College London

    Contributors

    Daniel M. Altmann, Jeremy D. Pearson, Michael J. May, Sussan Nourshargh, Ann Ager, Virginia Calder, John Greenwood, H. L. C. Beynon, P. Athanassiou, K. A. Davies, R. J. Moots, P. Emery, Abeed A. Pall, Caroline O. S. Savage, M. J. Dillon, Carla Zoja, Guiseppe Remuzzi, John R. Bradley

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