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Inherited Susceptibility to Cancer
Clinical, Predictive and Ethical Perspectives

£68.00

Shirley Hodgson, Gareth Evans, Howard Cuckle, Bartha Maria Knoppers, Beatrice Godard, Dorothy Nelkin, June Peters, Gene Feder, Michael Modell, Pamela St. Jean, Nicholas Schork, Louise Hosking, Karin Au, Philippe Schork, Tamar Flanders, William Foulkes, Steven Narod, Eamonn Maher, Bonnie King, David Hogg, Martin Ruttledge, Guy Rouleau, Nicholas Hayward, David Goudie, Harriet Feilotter, Lois Mulligan, Zoltan Trizna, Stimson Schantz, A. Malcolm Taylor, Kathy Pritchard-Jones
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  • Date Published: March 2009
  • availability: Available
  • format: Paperback
  • isbn: 9780521104746

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About the Authors
  • Many cancers, both common and rare, are known to have a hereditary predisposition and advances in genetics have clarified the risks and in some cases the mechanisms of cancer developing in an individual. First published in 1998, this important contribution to the literature of cancer genetics covers all the key issues, reviewing both the technology behind genetic risk assessment and the ethical dilemmas it poses. It is divided into two parts. The first deals with ethical, legal and social issues. The second systematically outlines current knowledge of the inheritance patterns of many different cancer types, both from a site-by-site perspective and for special groups. This authoritative volume will be of interest to oncologists, physicians and surgeons in other specialities and to health professionals in the areas of primary care, counselling and cancer risk assessment.

    Reviews & endorsements

    'Outlines succinctly our current knowledge of the inheritance patterns of many different cancer types. Such information needs to be readily available to counsel patients and their families in cancer clinics and increasingly in the primary care setting. This authoritative book will be of great use to all professionals involved in providing cancer care.' Karol Sikora, Imperial College School of Medicine

    'Foulkes and Hodgson have assembled a group of visionary contributors who not only portray the state of cancer genetics, but also provide helpful glimpses of the future for clinicians and researchers alike.' Francis S. Collins, National Human Genome Research Institute

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    Product details

    • Date Published: March 2009
    • format: Paperback
    • isbn: 9780521104746
    • length: 472 pages
    • dimensions: 229 x 152 x 27 mm
    • weight: 0.69kg
    • contains: 25 b/w illus. 33 tables
    • availability: Available
  • Table of Contents

    Part I. Ethical, legal and social issues, screening, counselling, gene and mutation detection:
    1. The inherited basis of cancer Shirley Hodgson and Gareth Evans
    2. Screening for cancer in those at high risk as a result of genetic susceptibility Howard Cuckle
    3. Ethical and legal perspectives on inherited cancer susceptibility Bartha Maria Knoppers and Beatrice Godard
    4. Cancer genetics and public expectations Dorothy Nelkin
    5. Genetic counselling June Peters
    6. Cancer genetics in primary care Gene Feder and Michael Modell
    7. Genetic epidemiologic approaches to finding genes that influence susceptibility to cancer Pamela St. Jean and Nicholas Schork
    8. Mutation detection Louise Hosking, Karin Au and Philippe Schork
    Part II. Hereditary contribution to cancer: site-by-site and special groups:
    9. Cancers of the digestive system Tamar Flanders and William Foulkes
    10. Cancers of the breast, ovary and uterus William Foulkes and Steven Narod
    11. Cancers of the kidney and urothelium Eamonn Maher
    12. Cancers of the prostate and testes Steven Narod, Bonnie King and David Hogg
    13. The neurofibromatoses and other neuro-oncological syndromes Martin Ruttledge and Guy Rouleau
    14. Malignant melanoma Nicholas Hayward
    15. Non-melanoma skin cancer David Goudie
    16. Endocrine cancers Harriet Feilotter and Lois Mulligan
    17. Tobacco-related cancers of the respiratory and upper digestive tract Zoltan Trizna and Stimson Schantz
    18. Inherited abnormalities of DNA processing and predisposition to cancer A. Malcolm Taylor
    19. Childhood cancer Kathy Pritchard-Jones
    20. Late-breaking developments William Foulkes and Shirley Hodgson
    Index.

  • Editors

    William D. Foulkes, McGill University, Montréal

    Shirley V. Hodgson, South Thames Regional Genetics Centre, London

    Contributors

    Shirley Hodgson, Gareth Evans, Howard Cuckle, Bartha Maria Knoppers, Beatrice Godard, Dorothy Nelkin, June Peters, Gene Feder, Michael Modell, Pamela St. Jean, Nicholas Schork, Louise Hosking, Karin Au, Philippe Schork, Tamar Flanders, William Foulkes, Steven Narod, Eamonn Maher, Bonnie King, David Hogg, Martin Ruttledge, Guy Rouleau, Nicholas Hayward, David Goudie, Harriet Feilotter, Lois Mulligan, Zoltan Trizna, Stimson Schantz, A. Malcolm Taylor, Kathy Pritchard-Jones

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