Skip to content
Register Sign in Wishlist

Systems Biology
Properties of Reconstructed Networks


  • Date Published: April 2006
  • availability: Available
  • format: Hardback
  • isbn: 9780521859035

£ 62.99

Add to cart Add to wishlist

Other available formats:

Looking for an inspection copy?

This title is not currently available on inspection

Product filter button
About the Authors
  • Genome sequences are now available that enable us to determine the biological components that make up a cell or an organism. The discipline of systems biology examines how these components interact and form networks, and how the networks generate whole cell functions corresponding to observable phenotypes. This textbook, devoted to systems biology, describes how to model networks, how to determine their properties, and how to relate these to phenotypic functions. The prerequisites are some knowledge of linear algebra and biochemistry. Though the links between the mathematical ideas and biological processes are made clear, the book reflects the irreversible trend of increasing mathematical content in biology education. Therefore to assist both teacher and student, in an associated website Palsson provides problem sets, projects and Powerpoint slides, and keeps the presentation in the book concrete with illustrative material and experimental results.

    • The first textbook in the new field of systems biology
    • An associated website provides slides, projects and problems
    • Features an open layout, summary points, guides to literature and lots of illustrations
    Read more

    Reviews & endorsements

    '… [deserves] serious attention from any quantitative scientist or physicist who hopes to learn about modern biology … a welcome departure from the typical biology textbook … a very readable introduction to the subject … this is an exciting time for biology. The author exposes readers to enough material that the research literature in quantitative systems biology should become accessible.' Physics Today

    Customer reviews

    Not yet reviewed

    Be the first to review

    Review was not posted due to profanity


    , create a review

    (If you're not , sign out)

    Please enter the right captcha value
    Please enter a star rating.
    Your review must be a minimum of 12 words.

    How do you rate this item?


    Product details

    • Date Published: April 2006
    • format: Hardback
    • isbn: 9780521859035
    • length: 336 pages
    • dimensions: 261 x 20 x 181 mm
    • weight: 0.8kg
    • availability: Available
  • Table of Contents

    1. Introduction
    2. Basic concepts in systems biology
    Part I. Reconstruction of Biochemical Networks:
    3. Metabolic networks
    4. Regulatory networks
    5. Signalling networks
    Part II. Mathematical Representation of Reconstructed Networks:
    6. Basic features of S
    7. Topological properties
    8. Fundamental subspaces
    9. Null space of S
    10. The left null space of S
    11. The row and column spaces of S
    Part III. Capabilities of Reconstructed Networks:
    12. Dual causality
    13. Properties of solution spaces
    14. Sampling properties of solution spaces
    15. Finding functional states
    16. Parametric sensitivity
    17. Epilogue
    Appendix A: nomenclature and abbreviations
    Appendix B: E. coli core metabolic network

  • Author

    Bernhard Ø. Palsson, University of California, San Diego
    Bernhard Ø. Palsson, Professor of Bioengineering and Adjunct Professor of Medicine, University of California, San Diego.

Sign In

Please sign in to access your account


Not already registered? Create an account now. ×

Sorry, this resource is locked

Please register or sign in to request access. If you are having problems accessing these resources please email

Register Sign in
Please note that this file is password protected. You will be asked to input your password on the next screen.

» Proceed

You are now leaving the Cambridge University Press website. Your eBook purchase and download will be completed by our partner Please see the permission section of the catalogue page for details of the print & copy limits on our eBooks.

Continue ×

Continue ×

Continue ×

Find content that relates to you

Join us online

This site uses cookies to improve your experience. Read more Close

Are you sure you want to delete your account?

This cannot be undone.


Thank you for your feedback which will help us improve our service.

If you requested a response, we will make sure to get back to you shortly.

Please fill in the required fields in your feedback submission.