Skip to content
Register Sign in Wishlist

G Protein-Coupled Receptors
Structure, Signaling, and Physiology

£124.00

textbook
Torsten Schoenberg, Kristin Schroeck, Claudia Staeubert, Andreas Russ, Adam J. Kuszak, Xiao Jie Yao, Sören G. F. Rasmussen, Brian K. Kobilka, Roger K. Sunahara, Graeme Milligan, Jean Phillipe Pin, Damien Maurell, Laetitia Comps-Agrar, Carine Monnier, Marie-Laure Rives, Etienne Doumazane, Philippe Rondard, Thierry Durroux, Laurent Prézeau, Erin Trinquet, Ahmed Hasbi, Brian F. O'Dowd, Susan R. George, Mario Mellado, Carlos Martinez-A., Jose Miguel Rodgriguez-Frade, Stefan Offermanns, Peter Hein, José Vázquez-Prado, J. Silvio Gutkind, Karin F. K. Ejendal, Julie A. Przybyla, Val J. Watts, Zhongzhen Nie, Yehia Daaka, Ralf Heilker, Michael Wolff, Ivan Toma Vranesic, Daniel Hoyer, Terry Kenakin, Michele Ciccarelli, J. Kurt Chuprun, Walter J. Koch, Richard M. O'Connor, John F. Cryan, Rosa Lopez Almagro, Gema Tarrason, Nuria Godessart, Georges Rawadi
View all contributors
  • Date Published: December 2010
  • availability: In stock
  • format: Hardback
  • isbn: 9780521112086

£ 124.00
Hardback

Add to cart Add to wishlist

Other available formats:
eBook


Looking for an inspection copy?

This title is not currently available on inspection

Description
Product filter button
Description
Contents
Resources
Courses
About the Authors
  • Provides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs). Recent advances include the first mammalian non-rhodopsin GPCR structures and reconstitution of purified GPCRs into membrane discs for defined studies, novel signaling features including oligomerization, and advances in understanding the complex ligand pharmacology and physiology of GPCRs, in new assay technologies and drug targeting. The authors take time to detail the importance of the pathophysiological function and drug targeting of GPCRs, specifically β-adrenoceptors in cardiovascular and respiratory diseases, metabotropic glutamate receptors in CNS disorders, S1P receptors in the immune system, and Wnt/Frizzled receptors in osteoporosis. This book will be invaluable to researchers and graduate students in academia and industry who are interested in the GPCR field.

    • Provides a broad overview of G-protein coupled receptors (GPCRs), including the first mammalian non-rhodopsin GPCR structures, as well as the techniques used to study them
    • Discusses GPCRs as drug targets - GPCRs constitute the single superfamily of proteins most targeted by currently marketed drugs
    • Covers pathophysiological function of GPCRs, specifically in cardiovascular and respiratory diseases, central nervous system disorders, the immune system and in osteoporosis
    Read more

    Customer reviews

    Not yet reviewed

    Be the first to review

    Review was not posted due to profanity

    ×

    , create a review

    (If you're not , sign out)

    Please enter the right captcha value
    Please enter a star rating.
    Your review must be a minimum of 12 words.

    How do you rate this item?

    ×

    Product details

    • Date Published: December 2010
    • format: Hardback
    • isbn: 9780521112086
    • length: 446 pages
    • dimensions: 260 x 184 x 24 mm
    • weight: 1.08kg
    • contains: 58 b/w illus. 23 tables
    • availability: In stock
  • Table of Contents

    Part I. Advances in GPCR Protein Research:
    1. The evolution of the repertoire and structure of G protein-coupled receptors Torsten Schoenberg, Kristin Schroeck, Claudia Staeubert and Andreas Russ
    2. Functional studies of isolated GPCR-G protein complexes in the membrane bilayer of lipoprotein particles Adam J. Kuszak, Xiao Jie Yao, Sören G. F. Rasmussen, Brian K. Kobilka and Roger K. Sunahara
    Part II. Oligomerization of GPCRs:
    3. GPCR-G protein fusions: use in functional dimerization analysis Graeme Milligan
    4. Time-resolved FRET approaches to study GPCR complexes Jean Phillipe Pin, Damien Maurell, Laetitia Comps-Agrar, Carine Monnier, Marie-Laure Rives, Etienne Doumazane, Philippe Rondard, Thierry Durroux, Laurent Prézeau and Erin Trinquet
    5. Signaling of dopamine receptor homo- and hetero-oligomers Ahmed Hasbi, Brian F. O'Dowd and Susan R. George
    6. Functional consequences of chemokine receptor dimerization Mario Mellado, Carlos Martinez-A. and Jose Miguel Rodgriguez-Frade
    Part III. GPCR Signaling Features:
    7. G protein functions identified using genetic mouse models Stefan Offermanns
    8. Kinetics of GPCR, G protein and effector activation Peter Hein
    9. RGS-RhoGEFs and other RGS multidomain proteins as effector molecules in GPCR-dependent and GPCR-independent cell signaling José Vázquez-Prado and J. Silvio Gutkind
    10. Adenylyl cyclase isoform-specific signaling of GPCRs Karin F. K. Ejendal, Julie A. Przybyla and Val J. Watts
    11. G protein-independent and β arrestin-dependent GPCR signaling Zhongzhen Nie and Yehia Daaka
    12. Assays to read GPCR modulation and signaling Ralf Heilker and Michael Wolff
    Part IV. Ligand Pharmacology of GPCRs:
    13. Quantifying allosteric ligand-receptor interactions Ivan Toma Vranesic and Daniel Hoyer
    14. 7TM Receptor functional selectivity Terry Kenakin
    Part V. Physiological Functions and Drug Targeting of GPCRs:
    15. Beta adrenergic receptors in cardiovascular and respiratory diseases Michele Ciccarelli, J. Kurt Chuprun and Walter J. Koch
    16. Role of metabotropic glutamate receptors in CNS disorders Richard M. O'Connor and John F. Cryan
    17. S1P receptor agonists, a novel generation of immunosuppressants Rosa Lopez Almagro, Gema Tarrason and Nuria Godessart
    18. Wnt/Frizzled receptor signaling in osteoporosis Georges Rawadi.

  • Editors

    Sandra Siehler, Novartis Institute for Biomedical Research
    Dr Siehler is a Research Investigator at the Novartis Institute for Biomedical Research in Basel, Switzerland. Dr Siehler is a member of the American Society for Pharmacology and Experimental Therapeutics and the British Pharmacological Society.

    Graeme Milligan, University of Glasgow
    Dr Milligan is Professor of Molecular Pharmacology at the University of Glasgow. He is actively involved in numerous associations, such as the Biochemical Society and British Pharmacological Society. Dr Milligan was awarded the Ariens Award for Pharmacology from the Dutch Pharmacological Society in 2006.

    Contributors

    Torsten Schoenberg, Kristin Schroeck, Claudia Staeubert, Andreas Russ, Adam J. Kuszak, Xiao Jie Yao, Sören G. F. Rasmussen, Brian K. Kobilka, Roger K. Sunahara, Graeme Milligan, Jean Phillipe Pin, Damien Maurell, Laetitia Comps-Agrar, Carine Monnier, Marie-Laure Rives, Etienne Doumazane, Philippe Rondard, Thierry Durroux, Laurent Prézeau, Erin Trinquet, Ahmed Hasbi, Brian F. O'Dowd, Susan R. George, Mario Mellado, Carlos Martinez-A., Jose Miguel Rodgriguez-Frade, Stefan Offermanns, Peter Hein, José Vázquez-Prado, J. Silvio Gutkind, Karin F. K. Ejendal, Julie A. Przybyla, Val J. Watts, Zhongzhen Nie, Yehia Daaka, Ralf Heilker, Michael Wolff, Ivan Toma Vranesic, Daniel Hoyer, Terry Kenakin, Michele Ciccarelli, J. Kurt Chuprun, Walter J. Koch, Richard M. O'Connor, John F. Cryan, Rosa Lopez Almagro, Gema Tarrason, Nuria Godessart, Georges Rawadi

Sign In

Please sign in to access your account

Cancel

Not already registered? Create an account now. ×

Sorry, this resource is locked

Please register or sign in to request access. If you are having problems accessing these resources please email lecturers@cambridge.org

Register Sign in
Please note that this file is password protected. You will be asked to input your password on the next screen.

» Proceed

You are now leaving the Cambridge University Press website. Your eBook purchase and download will be completed by our partner www.ebooks.com. Please see the permission section of the www.ebooks.com catalogue page for details of the print & copy limits on our eBooks.

Continue ×

Continue ×

Continue ×

Find content that relates to you

Join us online

This site uses cookies to improve your experience. Read more Close

Are you sure you want to delete your account?

This cannot be undone.

Cancel

Thank you for your feedback which will help us improve our service.

If you requested a response, we will make sure to get back to you shortly.

×
Please fill in the required fields in your feedback submission.
×