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Parasite Neuromusculature and its Utility as a Drug Target

Parasite Neuromusculature and its Utility as a Drug Target

£27.99

A. G. Maule, Tim A. Day, M. E. Selkirk, O. Lazari, J. B. Matthews, P. Ribeiro, F. El-Shehabi, N. Patocka, P. McVeigh, M. J. Kimber, E. Novozhilova, T. A. Day, J. J. Vermeire, J. E. Humphries, T. P. Yoshino, R. J. Martin, S. Verma, M. Levandoski, C. L. Clark, H. Qian, M. T. Stewart, A. P. Robertson, A. J. Wolstenholme, A. T. Rogers, R. M. Greenberg, C. Li, M. J. Kimber, C. C. Fleming, A. Mousley, D. W. Halton, N. J. Marks, K. Greenwood, T. Williams, T. Geary, N. C. Sangster, J. Song, J. Demeler
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  • Date Published: October 2006
  • availability: In stock
  • format: Paperback
  • isbn: 9780521691789

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  • Nerve and muscle systems in helminth parasites interact in a highly co-ordinated manner to control movements associated with alimentation, reproduction, locomotion and attachment. All metazoan parasites rely on some or all of these activities for their survival. For a long time it has been known that neuromuscular function in parasites is susceptible to chemotherapeutic attack, and that compromising this aspect of parasite biology is sufficient to cure many parasite infections. This volume outlines the latest research in this area, showing why this system is so amenable to drug intervention and outlining potential targets for new treatments. Written by experts in the field, this volume will be invaluable to anyone interested in the molecular biology, physiology and biochemistry of parasites as well as those looking to exploit these for the creation of new treatments.

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    Product details

    • Date Published: October 2006
    • format: Paperback
    • isbn: 9780521691789
    • length: 202 pages
    • dimensions: 298 x 212 x 10 mm
    • weight: 0.624kg
    • contains: 18 tables
    • availability: In stock
  • Table of Contents

    Preface A. G. Maule and Tim A. Day
    Functional genomics of nematode acetylcholinesterases, M. E. Selkirk, O. Lazari and J. B. Matthews
    Classical transmitters and their receptors in flatworms P. Ribeiro, F. El-Shehabi and N. Patocka
    Neuropeptide signalling systems in flatworms P. McVeigh, M. J. Kimber, E. Novozhilova and T. A. Day
    Signal transduction in larval trematodes: putative systems associated with regulating larval motility and behaviour J. J. Vermeire, J. E. Humphries and T. P. Yoshino
    Drug resistance and neurotransmitter receptors of nematodes: recent studies on the mode of action of levamisole R. J. Martin, S. Verma, M. Levandoski, C. L. Clark, H. Qian, M. T. Stewart and A. P. Robertson
    Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics A. J. Wolstenholme and A. T. Rogers
    Ca2+ signalling, voltage-gated Ca2+ channels and praziquantel in flatworm neuromusculature R. M. Greenberg
    The ever-expanding neuropeptide gene families in the nematode Caenorhabditis elegans C. Li
    Neuromuscular function in plant parasitic nematodes: a target for novel control strategies? M. J. Kimber and C. C. Fleming
    Inter-phyla studies on neuropeptides: the potential for broad-spectrum anthelmintic and/or endectocide discovery A. Mousley, A.G. Maule, D. W. Halton and N. J. Marks
    Nematode neuropeptide receptors and their development as anthelmintic screens K. Greenwood, T. Williams and T. Geary
    Resistance as a tool for discovering and understanding targets in parasite neuromusculature N. C. Sangster, J. Song and J. Demeler.

  • Editors

    Aaron G. Maule, Queen's University Belfast

    T. A. Day, Iowa State University

    L. H. Chappell, University of Aberdeen

    Contributors

    A. G. Maule, Tim A. Day, M. E. Selkirk, O. Lazari, J. B. Matthews, P. Ribeiro, F. El-Shehabi, N. Patocka, P. McVeigh, M. J. Kimber, E. Novozhilova, T. A. Day, J. J. Vermeire, J. E. Humphries, T. P. Yoshino, R. J. Martin, S. Verma, M. Levandoski, C. L. Clark, H. Qian, M. T. Stewart, A. P. Robertson, A. J. Wolstenholme, A. T. Rogers, R. M. Greenberg, C. Li, M. J. Kimber, C. C. Fleming, A. Mousley, D. W. Halton, N. J. Marks, K. Greenwood, T. Williams, T. Geary, N. C. Sangster, J. Song, J. Demeler

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