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Hepatitis C Virus
From Laboratory to Clinic

$134.00 USD

  • Date Published: January 2005
  • availability: This ISBN is for an eBook version which is distributed on our behalf by a third party.
  • format: Adobe eBook Reader
  • isbn: 9780511032073

$ 134.00 USD
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About the Authors
  • Hepatitis C infects 170 million people worldwide, and has been labelled the 'silent epidemic' as a result of its concealed attack on the liver. This multidisciplinary overview covers basic concepts related to the discovery of the virus, development of serological and nucleic acid tests to detect infection, the structure of the virus genome, generation of virus gene products, and proposed replication scheme. It then goes on to introduce the epidemiology, transmission, pathogenesis of infection, the development of hepatocellular carcinoma associated with chronic virus infection, and current strategies for treatment. The book then discusses advances in cell culture systems, animal models of infection, and emerging treatments and vaccine development. Through its coverage of basic science, clinical consequences, and methods of research, this integrated and accessible account will be of immense value to biomedical scientists and clinicians alike, and a useful introduction for all those studying the virus and its effects.

    • Combines basic science, clinical aspects and laboratory approaches to investigation
    • Extensively cross-referenced for easy access to concepts
    • An accessible introduction to a complex field
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    Reviews & endorsements

    'The diligent reader of this book will come away with a thorough grounding in the virology and immunopathology of hepatitis C, know what the major sources of further information are, and understand why this infection is at once enigmatic, insidiously progressive, difficult to treat and hard to immunize against. Thoroughly recommended! Epidemiology and Infection

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    Product details

    • Date Published: January 2005
    • format: Adobe eBook Reader
    • isbn: 9780511032073
    • contains: 9 b/w illus. 13 tables
    • availability: This ISBN is for an eBook version which is distributed on our behalf by a third party.
  • Table of Contents

    Preface
    Part I. Basic Principles:
    1. Background
    2. The virus
    3. Epidemiology and transmission
    4. Natural history of infection
    5. Pathogenesis of infection
    6. HCV and hepatocellular carcinoma
    7. Extrahepatic sites for hepatatis C
    8. HCV and autoimmune diseases
    9. Clinical aspects of the disease
    10. Current therapeutic approaches
    11. NS5A and interferon resistance
    Part II. Recent Advances:
    12. Propagation of virus in culture
    13. Understanding the natural history of HCV
    14. HCV animal models
    15. Vaccine research
    Part III. Experimental Approaches:
    16. New systems to understand HCV biology
    17. New antiviral screening assays
    18. Antiviral gene therapy
    Part IV. Protocols and Techniques:
    19. Sample collection, preparation and storage
    20. HCV RNA in blood and tissue samples
    21. HCV RNA genotypes and quasispecies
    22. Replication of HCV in tissue culture
    23. NS3 protease, helicase and NTPase
    24. Characterization of NS5B
    Part V. Outstanding Questions and Emerging Areas for Investigation
    References
    Index.

  • Author

    Mark A. Feitelson, Thomas Jefferson University, Philadelphia
    Mark A. Feitelson, Ph.D. is currently Professor in the Department of Pathology, Anatomy and Cell Biology. He has a secondary appointment in the Department of Microbiology and Immunology and is a member of the Kimmel Cancer Center at Thomas Jefferson University. In addition, he is head of the Molecular Diagnostics Laboratory in Microbiology for Thomas Jefferson University Hospital. Prior to his transfer to Jefferson Medical College, Dr Feitelson trained with the nobel laureate Dr Baruch S. Blumberg at the Fox Chase Cancer Center. Dr Feitelson has been working on the biology and pathogenesis of hepatitis B for more than 20 years, and has recently started a similar research program in hepatitis C.

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