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Cancer Metastasis
Biologic Basis and Therapeutics

Isaiah J. Fidler, Harold L. Moses, Janet E. Price, Elisa C. Woodhouse, Kathleen Kelly, Wayne S. Kendal, Cristina Hidalgo-Carcedo, Erik Sahai, Devanand Sarkar, Paul B. Fisher, Brunilde Gril, Russell Szmulewitz, Joshua Collins, Jennifer Taylor, Carrie Rinker-Schaeffer, Patricia Steeg, Jean-Claude Marshall, Bedrich L. Eckhardt, Tracey L. Smith, Robin L. Anderson, Wadih Arap, Renata Pasqualini, Amaia Lujambio, Manel Esteller, Nigel P. S. Crawford, Kent W. Hunter, Futoshi Okada, Hiroshi Kobayashi, Lilian Soon, Anthony Tachtsidis, Sandra Fok, Elizabeth D. Williams, Donald F. Newgreen, Erik W. Thompson, Wen Liu, Kounosuke Watabe, Ann F. Chambers, Sunhwa Kim, Michael Karin, Steven D. Mason, Johanna A. Joyce, Barbara Fingleton, Marianna Papaspyridonos, David Lyden, Rosandra N. Kaplan, Suzanne A. Eccles, Yibin Kang, Julio A. Aguirre-Ghiso, Daniel F. Alonso, Eduardo F. Farias, Tara Karnezis, Ramin Shayan, Marc G. Achen, Steven A. Stacker, Nancy E. Davidson, Chand Khanna, Lee Helman, Nai-Kong Cheung, Brian H. Kushner, Ira J. Dunkel, David H. Abramson, Matthew C. Tate, Mitchel S. Berger, Sarbani Ghosh-Laskar, Jai Prakash Agarwal, Indranil Mallick, Ketayun Dinshaw, Ahmad A. Tarhini, John M. Kirkwood, Takako Eguchi Nakajima, Yasuhide Yamada, José Eduardo M. Cunha, Marcos V. Perini, Daniela Freitas, Zhao-You Tang, Lun-Xiu Qin, Andrea Wang-Gillam, A. Craig Lockhart, Joel Picus, Rafael Rosell, Miquel Taron, David Jablons, R. Michael Tuttle, Jean-Jacques Patard, Stéphane Culine, Alain Ravaud, Neveen Said, Dan Theodorescu, G. David Roodman, Patrick G. Morris, Heather L. McArthur, Clifford A. Hudis, Sarah M. Temkin, S. Diane Yamada, Kosuke Mizutani, Russell S. Taichman, Kenneth J. Pienta, M. Houman Fekrazad, Robert Hromas, Richard Lauer, Mariaelena Pierobon, Alessandra Luchini, Alessandra Silvestri, Virginia Espina, Emanuel F. Petricoin, Lance A. Liotta, Klaus Pantel, Harriet Wikman, Catherine Alix-Panabieres, Katharina Effenberger, Sabine Riethdorf, Robert H. I. Andtbacka, Jeffrey E. Gershenwald, Yufang Hu, Mai Johnson, Frederic Pouliot, Lily Wu, Robert E. Coleman, Boris Kobrinsky, Simon Karpatkin, David L. Green, Randy L. Scherer, Hanako Kobayashi, Kimberly Boelte, P. Charles Lin, William Cruz-Munoz, Giulio Francia, Robert S. Kerbel, Pier-Luigi Lollini, Carla De Giovanni, Patrizia Nanni, Rob J. Jones, Tim P. Green, Paul Elvin, John H. Heinzerling, Jaeho Cho, Hak Choy, George W. Sledge Jr.
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  • Date Published: June 2011
  • availability: In stock
  • format: Hardback
  • isbn: 9780521887212

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  • Metastasis is responsible for a large burden of morbidity and mortality among cancer patients, and currently few therapies specifically target metastatic disease. Further scientific dissection of the underlying pathways is required to pave the way for new therapeutic targets. This groundbreaking new text comprehensively covers the processes underlying cancer metastasis and the clinical treatment of metastatic disease. Whereas previous volumes have been compendia of laboratory research articles, the internationally renowned authors of this volume have summarized the state-of-the-art research in the metastasis field. A major section covers the cellular and molecular pathways of metastasis and experimental techniques and the systems and models applied in this field. Subsequently, the clinical aspects of the major cancer types are considered, focusing on disease-specific research and therapeutic approaches to metastatic disease. The focus is on novel pathophysiological insights and emerging therapies; future directions for research and unmet clinical needs are also discussed.

    • Describes the processes underlying cancer metastasis and the clinical treatment of metastatic disease
    • Includes contributions from the top researchers and clinicians in the cancer field
    • Divided into two sections to incorporate the research aspect as well as the clinical studies of cancer metastasis
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    Product details

    • Date Published: June 2011
    • format: Hardback
    • isbn: 9780521887212
    • length: 660 pages
    • dimensions: 287 x 223 x 31 mm
    • weight: 2.05kg
    • contains: 87 b/w illus. 76 colour illus. 40 tables
    • availability: In stock
  • Table of Contents

    Overview: biology is the foundation of therapy
    Part I. Basic Research: Introduction to basic research
    Section 1. Models and Tools for Metastasis Studies:
    1. Animal models of cancer metastasis
    2. Drosophila and zebrafish: genetic models for cancer metastasis
    3. Computational models
    4. Intravital microscopy to visualize invasion and metastasis
    Section 2. Genes:
    5. Metastasis-promoting genes
    6. The role of metastasis suppressor genes in metastasis
    7. Stromal-derived factors that dictate organ-specific metastasis
    8. Metastasis genes: epigenetics
    9. Germline variation and other host determinants of metastatic potential
    10. The influence of aging and cellular senescence on metastasis
    Section 3. Various Properties of Cancer Cells:
    11. The continuum of epithelial mesenchymal transition - implication of hybrid states for migration and survival in development and cancer
    12. Apoptosis, anoikis, and senescence
    13. Metastatic inefficiency and tumor dormancy
    Section 4. Stromal Cells/Extracellular Matrix:
    14. Role of inflammation in metastatic progression
    15. Proteolytic cascades in invasion and metastasis
    16. Role of matrix metalloproteinases in tumor invasion and metastasis
    17. Cell-derived microvesicles and metastasis
    Section 5. Systemic Factors:
    18. Exploring the earliest steps in metastasis: the pre-metastatic niche
    19. Growth regulatory pathways contributing to organ selectivity of metastasis
    20. Determinants of organ-specific metastasis
    21. Function and expression of the uPA/uPAR system in cancer metastasis
    22. The lymphatics: on the route to cancer metastasis
    Part II. Clinical Research:
    23. Introduction to clinical research
    24. Sarcoma
    25. Neuroblastoma
    26. Retinoblastoma
    27. Primary brain tumors and cerebral metastases
    28. Head and neck cancer metastasis
    29. Cutaneous melanoma: therapeutic approaches for metastatic disease
    30. Gastric cancer metastasis
    31. Metastatic pancreatic cancer
    32. Metastasis of primary liver cancer
    33. Advances in management of metastatic colorectal cancer
    34. Lung cancer metastasis
    35. Metastatic thyroid cancer: evaluation and treatment
    36. Metastatic renal cell carcinoma
    37. Bladder cancer
    38. Bone complications of myeloma and lymphoma
    39. Breast metastasis
    40. Gynecologic malignancies
    41. Prostate cancer metastasis: thoughts on biology and therapeutics
    42. The biology and treatment of metastatic testicular cancer
    43. Applications of proteomics to metastasis diagnosis and individualized therapy
    44. Critical issues of research on circulating and disseminated tumor cells in cancer patients
    45.  Lymphatic mapping and sentinel lymph node biopsy
    46. Molecular imaging and metastasis
    47. Preserving bone health in malignancy and complications of bone metastases
    48. Role of platelets and thrombin in metastasis
    Section 6. Therapies:
    49. Cancer nanotechnology offers great promise for cancer research and therapy
    50. Metronomic chemotherapy for treatment of metastatic disease: from preclinical research to clinical trials
    51. Immunotherapy
    52. Discovery and development of drugs targeting tumor invasion and metastasis
    53. The role of radiotherapy in the treatment of metastatic disease
    54. Prospects for clinical trials of metastasis inhibitors.

  • Editors

    David Lyden, Weill Cornell Medical College, New York
    David Lyden is the Stavros S. Niarchos Associate Professor in Pediatrics and Cell and Developmental Biology at the Children's Cancer and Blood Foundation Laboratories at Weill Cornell Medical College. He is a Neuro-oncologist at Memorial Sloan-Kettering Cancer Center. Also, Dr Lyden is an Investigator of the Champalimaud Foundation, the first research, prevention and treatment center for metastatic disease. In 2007, he received the Presidential Medical Distinction Award from President Cavaco Silva of Portugal.

    Danny R. Welch, Weill Cornell Medical College, New York
    Danny R. Welch is Leonard H. Robinson Professor of Pathology at the University of Alabama, Birmingham. He actively holds numerous titles in various organizations, such as Co-Chair of the Program and Education Committees of American Association of Cancer Research, editor-in-chief of Clinical and Experimental Metastasis, and Chair of the Cancer Genetics Study Section at the National Institute of Health. Dr Welch has published six books and holds five patents.

    Bethan Psaila, Imperial College of Medicine, London
    Bethan Psaila is a Research Fellow at Imperial College of Medicine in London and Weill Cornell Medical College of New York. Dr Psaila is the recipient of a Fulbright Scholarship in Cancer Research and a Kay Kendall Leukaemia Fund Travelling Fellowship.

    Contributors

    Isaiah J. Fidler, Harold L. Moses, Janet E. Price, Elisa C. Woodhouse, Kathleen Kelly, Wayne S. Kendal, Cristina Hidalgo-Carcedo, Erik Sahai, Devanand Sarkar, Paul B. Fisher, Brunilde Gril, Russell Szmulewitz, Joshua Collins, Jennifer Taylor, Carrie Rinker-Schaeffer, Patricia Steeg, Jean-Claude Marshall, Bedrich L. Eckhardt, Tracey L. Smith, Robin L. Anderson, Wadih Arap, Renata Pasqualini, Amaia Lujambio, Manel Esteller, Nigel P. S. Crawford, Kent W. Hunter, Futoshi Okada, Hiroshi Kobayashi, Lilian Soon, Anthony Tachtsidis, Sandra Fok, Elizabeth D. Williams, Donald F. Newgreen, Erik W. Thompson, Wen Liu, Kounosuke Watabe, Ann F. Chambers, Sunhwa Kim, Michael Karin, Steven D. Mason, Johanna A. Joyce, Barbara Fingleton, Marianna Papaspyridonos, David Lyden, Rosandra N. Kaplan, Suzanne A. Eccles, Yibin Kang, Julio A. Aguirre-Ghiso, Daniel F. Alonso, Eduardo F. Farias, Tara Karnezis, Ramin Shayan, Marc G. Achen, Steven A. Stacker, Nancy E. Davidson, Chand Khanna, Lee Helman, Nai-Kong Cheung, Brian H. Kushner, Ira J. Dunkel, David H. Abramson, Matthew C. Tate, Mitchel S. Berger, Sarbani Ghosh-Laskar, Jai Prakash Agarwal, Indranil Mallick, Ketayun Dinshaw, Ahmad A. Tarhini, John M. Kirkwood, Takako Eguchi Nakajima, Yasuhide Yamada, José Eduardo M. Cunha, Marcos V. Perini, Daniela Freitas, Zhao-You Tang, Lun-Xiu Qin, Andrea Wang-Gillam, A. Craig Lockhart, Joel Picus, Rafael Rosell, Miquel Taron, David Jablons, R. Michael Tuttle, Jean-Jacques Patard, Stéphane Culine, Alain Ravaud, Neveen Said, Dan Theodorescu, G. David Roodman, Patrick G. Morris, Heather L. McArthur, Clifford A. Hudis, Sarah M. Temkin, S. Diane Yamada, Kosuke Mizutani, Russell S. Taichman, Kenneth J. Pienta, M. Houman Fekrazad, Robert Hromas, Richard Lauer, Mariaelena Pierobon, Alessandra Luchini, Alessandra Silvestri, Virginia Espina, Emanuel F. Petricoin, Lance A. Liotta, Klaus Pantel, Harriet Wikman, Catherine Alix-Panabieres, Katharina Effenberger, Sabine Riethdorf, Robert H. I. Andtbacka, Jeffrey E. Gershenwald, Yufang Hu, Mai Johnson, Frederic Pouliot, Lily Wu, Robert E. Coleman, Boris Kobrinsky, Simon Karpatkin, David L. Green, Randy L. Scherer, Hanako Kobayashi, Kimberly Boelte, P. Charles Lin, William Cruz-Munoz, Giulio Francia, Robert S. Kerbel, Pier-Luigi Lollini, Carla De Giovanni, Patrizia Nanni, Rob J. Jones, Tim P. Green, Paul Elvin, John H. Heinzerling, Jaeho Cho, Hak Choy, George W. Sledge Jr.

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