The authors explain how the whole dendritic arborization contributes to the generation of various output discharges and elucidate the mechanisms of the transfer function of all dendritic sites. Their alternative modelling approach to conventional models introduces the notion of a functional dendritic space, and they have concentrated on a detailed spatial description of the electrical states at all dendritic sites when the dendrites operate. By analyzing the electrical dendritic space in which all the signals are processed, the authors provide tools to explore the spatial dimension of the transient events well known by electrophysiologists. They demonstrate the mechanisms by which the operating dendrites decide how, in fine, the distributed synaptic inputs generate final various output discharges. Their approach reveals the mechanisms by which individual dendritic geometry determines the sequence of action potentials that is the neuronal code. An accompanying NeuronViewer allows readers to monitor the simulation of operating dendritic arborization.Read more
- Accompanying NeuronViewer and user guide allow the reader to monitor simulation of dendritic arborization online
- Includes quantitative morphology of neurons and simulations for step-by-step demonstration of the impact of geometry on electrical profiles of the dendrites
- Historical background is given to help understand the progress of neuronal modelling
Reviews & endorsements
'Dendritic trees come in all sorts of shapes and sizes. Their complexity and diversity lends a majesty and beauty to the task of understanding the brain. But are they more than just random protrusions? Could their very complexity and diversity be important for the computational properties of the brain? The authors are clear on this point, 'We strongly believe that the answer is yes indeed, as we attribute a specific role to every of these structural features in a harmonious working ensemble!' I am sure that readers of this book will also be convinced. The book progresses through careful treatment of the electrical properties of dendrites to how the geometry interacts with synaptic input to produce rich repertoires of firing output. It is an important book for experts and students of dendrites alike as well as an eye-opener for neuroscientists in every field.' Matthew Larkum, University of BernSee more reviews
'Electrical Dynamics of the Dendritic Space is a compelling treatise on the electrical properties of neuronal dendrites, from a modeling perspective. The authors Serge Korogod and Suzanne Tyč-Dumont do a super job in writing comprehensively on a topic of profound relevance to present day neuroscience.' Rodolfo Llinas, New York University Medical School
'The complex geometry of neuronal dendrites is one of the greatest challenges facing neuroscientists today. Serge Korogod and Suzanne Tyc-Dumont characterize the dendrites as an immense unknown. They have been pioneers in exploring this frontier. In this book they have distilled lifetimes of work by themselves and colleagues in France and the Ukraine to formulate new rules for how the electrical states of dendritic arborizations represent space and time in generating the neural code. In clear language they show how the interactions between these passive and active properties and dendritic geometry create different scales of dynamical dendritic space. New insights are provided into the significance of the dendrites of motoneurons, cerebellar Purkinje cells, and cortical pyramidal neurons. Their models available online give dramatic evidence for these insights. This is a key book for all those interested in dendrites and in the neural basis of cognition and behavior.' Gordon M. Shepherd, Yale University School of Medicine
Not yet reviewed
Be the first to review
Review was not posted due to profanity×
- Date Published: December 2009
- format: Hardback
- isbn: 9780521896771
- length: 224 pages
- dimensions: 254 x 180 x 16 mm
- weight: 0.62kg
- contains: 3 b/w illus. 14 colour illus.
- availability: In stock
Table of Contents
1. Definition of the neuron
2. 3D geometry of dendritic arborizations
3. Basics in bioelectricity
4. The cable theory and the dendrites
5. Voltage transfer over the dendrites
6. Current transfer over dendrites
7. Electrical structure of an artificial dendritic path
8. Electrical structure of a bifurcation
9. Geography of the dendritic space
10. Electrical structures of biological dendrites
11. Electrical structure of the whole arborization
12. Electrical structures in the 3D dendritic space
13. Dendritic space as coder of the temporal output patterns
14. Concluding remarks.
Find resources associated with this titleYour search for '' returned .
Type Name Unlocked * Format Size
This title is supported by one or more locked resources. Access to locked resources is granted exclusively by Cambridge University Press to lecturers whose faculty status has been verified. To gain access to locked resources, lecturers should sign in to or register for a Cambridge user account.
Please use locked resources responsibly and exercise your professional discretion when choosing how you share these materials with your students. Other lecturers may wish to use locked resources for assessment purposes and their usefulness is undermined when the source files (for example, solution manuals or test banks) are shared online or via social networks.
Supplementary resources are subject to copyright. Lecturers are permitted to view, print or download these resources for use in their teaching, but may not change them or use them for commercial gain.
If you are having problems accessing these resources please contact email@example.com.
Sorry, this resource is locked
Please register or sign in to request access. If you are having problems accessing these resources please email firstname.lastname@example.orgRegister Sign in