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Neuronal Substrates of Sleep and Epilepsy

Neuronal Substrates of Sleep and Epilepsy

  • Date Published: May 2003
  • availability: In stock
  • format: Hardback
  • isbn: 9780521817073


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About the Authors
  • Different states of vigilance and various paroxysmal disorders that occur during slow-wave sleep can have the same neural bases. Conventional wisdom holds that sleep is a resting state of the brain, with negligible activity of cortical neurons. Here, the author brings new evidence favoring the idea that during this behavioral state memory traces acquired during waking are consolidated. The author focuses on the coalescence of different sleep rhythms in interacting corticothalamic networks and on three types of paroxysmal disorders, namely spike-wave seizures as in absence epilepsy, Lennox-Gastaut seizures, and temporal-lobe epilepsy. Many physiological correlates of waking and sleep states as well as diverse types of epileptic seizures are also discussed. The book has copious illustrations with examples from in vivo, in vitro and 'in computo' studies, the majority coming from the author's own laboratory. Neuronal Substrates of Sleep and Epilepsy is essential reading for neuroscientists and clinical researchers.

    • The first major book to deal with the relationship between sleep and epilepsy
    • The author is a world authority on these topics, and has spent much of his scientific career researching various aspects of them
    • Profusely illustrated with data from the author's research
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    Reviews & endorsements

    '… invaluable to neuroscientists and clinical researchers of sleep. It will also prove useful to neurophysiologists and neurologists who have an interest in the biological basis of sleep and seizure disorders.' The Lancet

    'A remarkable tour de force from a master of integrative neurophysiology.' Neuroscience

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    Product details

    • Date Published: May 2003
    • format: Hardback
    • isbn: 9780521817073
    • length: 536 pages
    • dimensions: 255 x 198 x 33 mm
    • weight: 1.392kg
    • contains: 232 b/w illus. 10 colour illus.
    • availability: In stock
  • Table of Contents

    1. Pioneering steps in studies on sleep and epilepsy
    2. Neuronal types and circuits in sleep and epilepsy
    3. Neuronal properties, network operations and behavioral signs during sleep states and wakefulness
    4. Plastic changes in thalamocortical systems developing from low-frequency sleep oscillations
    5. Neuronal mechanisms of seizures.

  • Author

    Mircea Steriade, Université Laval, Québec
    Mircea Steriade is Professor and Head of the Laboratory of Neurophysiology at Laval University and is a member of the Royal Society of Canada (Academy of Sciences).

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