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Neurotransmitter Release and its Modulation

Neurotransmitter Release and its Modulation
Biochemical Mechanisms, Physiological Function and Clinical Relevance

K. Starke, R. D. Burgoyne, T. R. Cheek, P. Sneddon, M. R. Bennett, L. Stjärne, J. A. Brock, B. B. Fredholm, J. J. Reid, Z. Khalil, P. D. Marley, M. Joëls, E. R. de Kloet, H. Majewski, M. Barrington, D. Bleakman, R. J. Miller, A. R. Wakade, D. A. Przywara, B. H. C. Westerink, M. R. Boarder, K. R. Borkowski, P. Blier, C. de Montigny, S. Wonnacott, M. Göthert, L. A. Chahl, M. Willow, G. M. Nicholson, T. C. Westfall
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  • Date Published: August 1995
  • availability: Available
  • format: Paperback
  • isbn: 9780521446167

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  • The group of chemicals known collectively as neurotransmitters form the basis of a complex communication system between nerve cells. It is a system which is constantly subtly refined and regulated via the modulating action of other neurotransmitters, circulating hormones, the products of local tissues and the action of various drugs (from both medicinal and socially abused sources). Within this book, acknowledged authorities concisely describe the basic mechanisms involved in neurotransmitter release modulation in the different parts of the nervous system. This includes a quantitative evaluation of the significance of modulation, and a summary of both its biological ramifications and potential clinical relevance. The clear illustrations and descriptions create a valuable and easy to use reference resource for the non-specialist reader and neuroscientist alike. Clinicians, researchers and students should all find its contents of interest.

    • International team of contributors, acknowledged experts in this field
    • A comprehensive integrated approach covering both basic science and biological and clinical relevance
    • Clear descriptions and illustration provide easy accessibility for the non-specialist and student reader
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    Reviews & endorsements

    'This is an excellent book, which I thoroughly enjoyed reading … a valuable reference source for both non-specialists and neuroscientists alike. Indeed I scrapped my current lecture reference handout on this topic and replaced it with a reference to this book … modestly priced at £27.95 paperback … it doesn't overwhelm the students with unnecessary detail … very popular with my students already.' T. C. Cunnane, Experimental Physiology

    '… a series of incisive and interesting accounts … excellent clear presentation.' Roger Barker, Journal of Neurology, Neurosurgery, and Psychiatry

    '… very much a book for the neuropharmacologist and neurophysiologist … a well compiled and neatly produced volume.' André Jacowski, British Journal of Neurosurgery

    '… provides a detailed insight into 'a vivid science' relevant to much of current clinical practice.' British Medical Journal

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    Product details

    • Date Published: August 1995
    • format: Paperback
    • isbn: 9780521446167
    • length: 378 pages
    • dimensions: 246 x 189 x 20 mm
    • weight: 0.68kg
    • contains: 120 b/w illus. 11 tables
    • availability: Available
  • Table of Contents

    Part I. Neurotransmitter Release:
    1. Mechanisms of exocytosis and the central role of calcium
    2. Co-transmission
    3. Models and mechanisms of neurotransmission
    Part II. Modulation of Neurotransmitter Release: Basic Principles and Key Players:
    4. Modulation of neurotransmitter release
    5. Modulation by autoreceptors
    6. Modulation by heteroreceptors
    7. Modulation by hormones and local tissue factors
    8. Modulation by corticosteroid hormones
    Part III. Modulation of Neurotransmitter Release: The Cellular Mechanisms Involved:
    9. Second messenger pathways in the modulation of neurotransmitter release
    10. Regulation of calcium influx as a basis for modulation
    11. Calcium-independent modulation
    Part IV. Modulation of Neurotransmitter Release: Physiological Function:
    12. In vivo evidence for presynaptic modulation
    13. Modulation of secretion from neurosecretory cells
    Part V. Modulation of Neurotransmitter Release: Clinical Relevance:
    14. Possible role of presynaptic receptors in hypertension
    15. Monoamine neurones and antidepressant treatments
    16. Modulation of neurotransmitter release by some therapeutic and socially-used drugs
    17. Beneficial therapeutic interventions via manipulation of presynaptic modulatory mechanisms.

  • Editors

    David A. Powis, University of Newcastle, New South Wales

    Stephen J. Bunn, University of Newcastle, New South Wales

    Foreword

    Klaus Starke

    Contributors

    K. Starke, R. D. Burgoyne, T. R. Cheek, P. Sneddon, M. R. Bennett, L. Stjärne, J. A. Brock, B. B. Fredholm, J. J. Reid, Z. Khalil, P. D. Marley, M. Joëls, E. R. de Kloet, H. Majewski, M. Barrington, D. Bleakman, R. J. Miller, A. R. Wakade, D. A. Przywara, B. H. C. Westerink, M. R. Boarder, K. R. Borkowski, P. Blier, C. de Montigny, S. Wonnacott, M. Göthert, L. A. Chahl, M. Willow, G. M. Nicholson, T. C. Westfall

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